Cardiac conduction system abnormalities in ankylosing spondylitis: a cross-sectional study

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• 作者：Helena Forsblad-d’Elia (8)
  Hanna Wallberg (9)
  Eva Klingberg (8)
  Hans Carlsten (8)
  Lennart Bergfeldt (9)
  
• 关键词：Ankylosing spondylitis ; Spondyloarthritis ; Heart disease ; Inflammation ; Disease activity ; HLA B27
• 刊名：BMC Musculoskeletal Disorders
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：14
• 期：1
• 全文大小：202KB
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  24. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2474/14/237/prepub
  
• 作者单位：Helena Forsblad-d’Elia (8)
  Hanna Wallberg (9)
  Eva Klingberg (8)
  Hans Carlsten (8)
  Lennart Bergfeldt (9)
  
  8. Institute of Medicine, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Box 480, S-405 30, Gothenburg, Sweden
  9. Institute of Medicine, Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  

文摘

Background Cardiac conduction disturbances are common in spondyloarthropathies such as ankylosing spondylitis (AS). Whether their occurrence can be linked to signs and symptoms of rheumatic disease activity is an unsettled issue addressed in this study. Methods In this cross-sectional study patients with AS according to modified New York criteria but without psoriasis, inflammatory bowel disease, dementia, pregnancy, other severe diseases such as malignancy and difficulties in answering questionnaires were invited; and 210 participated (120 men), mean age 49?years (SD 13; range: 16-7). Questionnaires, physical examination, ECG, and laboratory tests were performed at the same visit. Results Cardiac conduction disturbances were common and diagnosed in 10-33%, depending on if conservative or less conservative predefined criteria were applied. They consisted mostly of 1st degree atrio-ventricular block and prolonged QRS duration, but one patient had a pacemaker and 7 more had complete bundle branch blocks. Conduction abnormalities were associated mainly with age, male gender and body weight, and not with laboratory measures of inflammation or with Bath Ankylosing Spondylitis Disease Activity Index. Neither were they associated with the presence of HLA B27, which was found in 87% of all patients; the subtype B270502 dominated in all patients. Conclusions Cardiac conduction abnormalities are common in AS, but not associated with markers of disease activity or specific B27 subtypes. Even relatively mild conduction system abnormalities might, however, indirectly affect morbidity and mortality.