Seasonal variations in serum 25-hydroxy vitamin D levels in a Swedish cohort

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• 作者：Eva Klingberg ; G?ran Oler?d ; Jan Konar ; Max Petzold ; Ola Hammarsten
• 关键词：Vitamin D ; Vitamin D deficiency ; Parathyroid hormone ; Ultraviolet light
• 刊名：Endocrine
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：49
• 期：3
• 页码：800-808
• 全文大小：658 KB
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• 作者单位：Eva Klingberg (1) (4)
  G?ran Oler?d (2)
  Jan Konar (2)
  Max Petzold (3)
  Ola Hammarsten (2)
  
  1. Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
  4. Department of Rheumatology, Sahlgrenska/SU, Gr?na str?ket 14, 41345, Gothenburg, Sweden
  2. Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
  3. Centre for Applied Biostatistics, Occupational and Environmental Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
  
• 刊物主题：Endocrinology; Diabetes; Internal Medicine; Science, general;
• 出版者：Springer US
• ISSN：1559-0100

文摘

To study seasonal inter-individual and intra-individual variations in serum 25-hydroxy vitamin D (25(OH)D) and to explore parameters associated with 25(OH)D in a healthy Swedish adult population. 540 blood donors (60?% men; mean age 41?±?13?years) and 75 thrombocyte donors (92?% men, aged 46?±?11?years) were included. Serum was collected during 12?months and analyzed for 25(OH)D and parathyroid hormone (S-iPTH). The blood donors answered questionnaires concerning vitamin D supplements, smoking, physical activity, sunbed use and sun holidays. Repeated serum samples were collected from the thrombocyte donors to study the intra-individual variations in S-25(OH)D. S-25(OH)D varied greatly over the year correlating with the intensity of the UV-B irradiation (r S?=?0.326; p?<?0.001). During January–March, a S-25(OH)D level below the thresholds of 50 and 75?nmol/L was observed in 58 and 88?%, respectively, and during July–September in 11 and 50?% (p?<?0.001). S-25(OH)D was negatively correlated with body mass index and S-iPTH, but was significantly higher in holiday makers in sunny destinations, sunbed users, non-smokers, and in the physically active. The intra-individual analyses showed a mean increase in S-25(OH)D by 8?nmol/L/month between April and August. Approximately 75?% had serum 25(OH)D values <75?nmol/L during 75?% of the year and 50?% had serum 25(OH)D <50?nmol/L during 50?% of the year. Serum 25(OH)D was strongly associated with parameters related to sun exposure, but only weakly with intake of vitamin D supplements.