Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study
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- 作者：Kim V. E. Braun ; Klodian Dhana ; Paul S. de Vries ; Trudy Voortman…
- 关键词：DNA methylation ; Lipids ; EWAS ; Triglycerides ; HDL ; C ; LDL ; C ; Total cholesterol ; Cohort
- 刊名：Clinical Epigenetics
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：9
- 期：1
- 全文大小：1159KB
- 刊物主题：Human Genetics; Gene Function;
- 出版者：BioMed Central
- ISSN：1868-7083
- 卷排序：9
文摘
BackgroundDNA methylation is a key epigenetic mechanism that is suggested to be associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation levels are associated with blood levels of triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol in 725 participants of the Rotterdam Study, a population-based cohort study. Subsequently, we sought replication in a non-overlapping set of 760 participants.