Proteomic analyses of limbic regions in neonatal male, female and androgen receptor knockout mice
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- 作者：Anna Zettergren ; Sara Karlsson ; Erik Studer ; Anna Sarvimäki…
- 关键词：Proteomics ; Sex differences ; Androgen receptor ; Neonatal ; Amygdala ; Hypothalamus
- 刊名：BMC Neuroscience
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：974KB
- 刊物主题：Neurosciences; Neurobiology; Animal Models;
- 出版者：BioMed Central
- ISSN：1471-2202
- 卷排序：18
文摘
BackgroundIt is well-established that organizational effects of sex steroids during early development are fundamental for sex-typical displays of, for example, mating and aggressive behaviors in rodents and other species. Male and female brains are known to differ with respect to neuronal morphology in particular regions of the brain, including the number and size of neurons, and the density and length of dendrites in nuclei of hypothalamus and amygdala. The aim of the present study was to use global proteomics to identify proteins differentially expressed in hypothalamus/amygdala during early development (postnatal day 8) of male, female and conditional androgen receptor knockout (ARNesDel) male mice, lacking androgen receptors specifically in the brain. Furthermore, verification of selected sexually dimorphic proteins was performed using targeted proteomics.