Bistability of the system of nitrite utilization by Escherichia Coli: Analysis of a mathematical model

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• 作者：N. A. Ri (14276)
  T. M. Khlebodarova (14276)
  V. V. Kogai (24276) (34276)
  S. I. Fadeev (24276) (34276)
  V. A. Likhoshvai (14276) (34276)
  
• 关键词：gene expression regulation ; Escherichia coli ; anaerobic respiration ; modeling ; bistability
• 刊名：Journal of Applied and Industrial Mathematics
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：7
• 期：2
• 页码：252-258
• 全文大小：534KB
• 参考文献：1. H. Wang and R. P. Gunsalus, 鈥淭he / nrfA and / nirB Nitrite Reductase Operons in / Escherichia coli Are Expressed Differently in Response to Nitrate Than to Nitrite,鈥?J. Bacteriol. trong class="a-plus-plus">82trong>, 5813鈥?822 (2000). ternal" href="http://dx.doi.org/10.1128/JB.182.20.5813-5822.2000">CrossRef
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• 作者单位：N. A. Ri (14276)
  T. M. Khlebodarova (14276)
  V. V. Kogai (24276) (34276)
  S. I. Fadeev (24276) (34276)
  V. A. Likhoshvai (14276) (34276)
  
  14276. Institute of Cytology and Genetics, pr. Akad. Lavrent鈥檈va 10, Novosibirsk, 630090, Russia
  24276. Sobolev Institute of Mathematics, pr. Akad. Koptyuga 4, Novosibirsk, 630090, Russia
  34276. Novosibirsk State University, ul. Pirogova 2, Novosibirsk, 630090, Russia
  
• ISSN：1990-4797

文摘

Some mathematical model is analyzed describing nitrite utilization by E. coli cells grown in a flow chemostat. The system is of interest from the standpoint of the analysis of the mechanisms by which a cell utilizes toxic substrates in respiration. It is demonstrated that the system admits the appearance of two stationary nitrite concentrations; thus, it becomes bistable. The range of the nitrite supply rate into the chemostat for which the model is bistable is determined. The model predicts the possibility of a spontaneous death of the culture in transition between stationary states.