A five-gene reverse transcription-PCR assay for pre-operative classification of breast fibroepithelial lesions

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• 作者：Wai Jin Tan ; Igor Cima ; Yukti Choudhury ; Xiaona Wei…
• 关键词：Phyllodes tumors ; Fibroadenomas ; Fibroepithelial lesions ; Prediction ; Multigene assay ; Core biopsy ; FFPE
• 刊名：Breast Cancer Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：18
• 期：1
• 全文大小：1,358 KB
• 刊物主题：Cancer Research; Oncology;
• 出版者：BioMed Central
• ISSN：1465-5411

文摘

Background Breast fibroepithelial lesions are biphasic tumors and include fibroadenomas and phyllodes tumors. Preoperative distinction between fibroadenomas and phyllodes tumors is pivotal to clinical management. Fibroadenomas are clinically benign while phyllodes tumors are more unpredictable in biological behavior, with potential for recurrence. Differentiating the tumors may be challenging when they have overlapping clinical and histological features especially on core biopsies. Current molecular and immunohistochemical techniques have a limited role in the diagnosis of breast fibroepithelial lesions. We aimed to develop a practical molecular test to aid in distinguishing fibroadenomas from phyllodes tumors in the pre-operative setting.