Selective inhibition of liver X receptor α-mediated lipogenesis in primary hepatocytes by licochalcone A
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- 作者：Gyun-Sik Oh ; Gang Gu Lee ; Jin Yoon ; Won Keun Oh ; Seung-Whan Kim
- 刊名：Chinese Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：10
- 期：1
- 全文大小：910 KB
- 刊物主题：Complementary & Alternative Medicine;
- 出版者：BioMed Central
- ISSN：1749-8546
文摘
Background Sterol regulatory element binding protein-1c (SREBP-1c) is a regulator of the lipogenic pathway and is transcriptionally activated by liver X receptor α (LXRα). This study aims to investigate phytochemicals inhibiting the autonomous transactivity of LXRα with potentials as SREBP-1c inhibitors. Licochalcone A (LicA) is a flavonoid isolated from licorice root of Glycyrrhiza plant.