Reversal of muscle atrophy by Zhimu and Huangbai herb pair via activation of IGF-1/Akt and autophagy signal in cancer cachexia

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• 作者：Pengwei Zhuang ; Jinbao Zhang ; Yan Wang ; Mixia Zhang ; Lili Song…
• 关键词：Cancer cachexia ; Skeletal muscle atrophy ; Zhimu and Huangbai herb pair ; Autophagy ; IGF ; 1/Akt
• 刊名：Supportive Care in Cancer
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：24
• 期：3
• 页码：1189-1198
• 全文大小：2,334 KB
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• 作者单位：Pengwei Zhuang (1) (2) (3)
  Jinbao Zhang (1) (4)
  Yan Wang (1) (2)
  Mixia Zhang (1) (2)
  Lili Song (1) (2)
  Zhiqiang Lu (1)
  Lu Zhang (1)
  Fengqi Zhang (1)
  Jing Wang (1)
  Yanjun Zhang (1) (2)
  Hongjun Wei (3)
  Hongyan Li (3)
  
  1. Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, #312 Anshanxi Road, Nankai District, Tianjin, 300193, China
  2. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
  3. Tianjin JF-Pharmaland Technology Development Co., Ltd, Tianjin, China
  4. Gansu University of Chinese Medicine, Lanzhou, Gansu, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Nursing
  Nursing Management and Research
  Pain Medicine
  Rehabilitation Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-7339

文摘

Purpose Muscle atrophy is the prominent clinical feature of cancer-induced cachexia. Zhimu and Huangbai herb pair (ZBHP) has been used since ancient China times and have been phytochemically investigated for constituents that might cause anti-cancer, diabetes, and their complication. In this study, the effects and mechanisms of ZBHP on reversal of muscle atrophy were explored.