Ciproxifan, an H3 receptor antagonist, improves short-term recognition memory impaired by isoflurane anesthesia

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• 作者：Fang Ding ; Limin Zheng ; Min Liu ; Rongfa Chen ; L. Stan Leung…
• 刊名：Journal of Anesthesia
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：30
• 期：4
• 页码：684-690
• 全文大小：456 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Anesthesiology
  
• 出版者：Springer Japan
• ISSN：1438-8359
• 卷排序：30

文摘

BackgroundExposure to volatile anesthetics has been reported to cause temporary or sustained impairments in learning and memory in pre-clinical studies. The selective antagonists of the histamine H3 receptors (H3R) are considered to be a promising group of novel therapeutic agents for the treatment of cognitive disorders. The aim of this study was to evaluate the effect of H3R antagonist ciproxifan on isoflurane-induced deficits in an object recognition task.