GAAP: Genome-organization-framework-Assisted Assembly Pipeline for prokaryotic genomes
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- 作者：Lina Yuan ; Yang Yu ; Yanmin Zhu ; Yulai Li ; Changqing Li ; Rujiao Li ; Qin Ma…
- 关键词：Core ; gene ; defined Genome Organizational Framework (cGOF) ; Scaffolding ; Rearrangement ; Prokaryotic genome
- 刊名：BMC Genomics
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：18
- 期：1-supp
- 全文大小：672KB
- 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
- 出版者：BioMed Central
- ISSN：1471-2164
- 卷排序：18
文摘
BackgroundNext-generation sequencing (NGS) technologies have greatly promoted the genomic study of prokaryotes. However, highly fragmented assemblies due to short reads from NGS are still a limiting factor in gaining insights into the genome biology. Reference-assisted tools are promising in genome assembly, but tend to result in false assembly when the assigned reference has extensive rearrangements.