p120-Catenin Is Critical for the Development of Invasive Lobular Carcinoma in Mice

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• 作者：Milou Tenhagen ; Sjoerd Klarenbeek…
• 关键词：p120 ; Mouse model ; Breast cancer ; Invasive lobular carcinoma
• 刊名：Journal of Mammary Gland Biology and Neoplasia
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：21
• 期：3-4
• 页码：81-88
• 全文大小：2128KB
• 刊物类别：Medicine
• 刊物主题：Oncology; Cancer Research;
• 出版者：Springer US
• ISSN：1573-7039
• 卷排序：21

文摘

Loss of E-cadherin expression is causal to the development of invasive lobular breast carcinoma (ILC). E-cadherin loss leads to dismantling of the adherens junction and subsequent translocation of p120-catenin (p120) to the cytosol and nucleus. Although p120 is critical for the metastatic potential of ILC through the regulation of Rock-dependent anoikis resistance, it remains unknown whether p120 also contributes to ILC development. Using genetically engineered mouse models with mammary gland-specific inactivation of E-cadherin, p120 and p53, we demonstrate that ILC formation induced by E-cadherin and p53 loss is severely impaired upon concomitant inactivation of p120. Tumors that developed in the triple-knockout mice were mostly basal sarcomatoid carcinomas that displayed overt nuclear atypia and multinucleation. In line with the strong reduction in ILC incidence in triple-knockout mice compared to E-cadherin and p53 double-knockout mice, no functional redundancy of p120 family members was observed in mouse ILC development, as expression and localization of ARVCF, p0071 or δ-catenin was unaltered in ILCs from triple-knockout mice. In conclusion, we show that loss of p120 in the context of the p53-deficient mouse models is dominant over E-cadherin inactivation and its inactivation promotes the development of basal, epithelial-to-mesenchymal-transition (EMT)-type invasive mammary tumors.