Mucosal vaccine delivery by non-recombinant spores of Bacillus subtilis
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- 作者：Ezio Ricca (1)
Loredana Baccigalupi (1)
Giuseppina Cangiano (1)
Maurilio De Felice (1)
Rachele Isticato (1)
1. Department of Biology ; Federico II University of Naples ; via Cinthia ; 80126 ; Naples ; Italy - 关键词：Vaccine vehicles ; Vaccine delivery ; Drug delivery ; Surface display
- 刊名：Microbial Cell Factories
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：13
- 期：1
- 全文大小：1,089 KB
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- 刊物主题：Biotechnology
Applied Microbiology
Environmental Engineering/Biotechnology - 出版者：BioMed Central
- ISSN：1475-2859
文摘
Development of mucosal vaccines strongly relies on an efficient delivery system and, over the years, a variety of approaches based on phages, bacteria or synthetic nanoparticles have been proposed to display and deliver antigens. The spore of Bacillus subtilis displaying heterologous antigens has also been considered as a mucosal vaccine vehicle, and shown able to conjugate some advantages of live microrganisms with some of synthetic nanoparticles. Here we review the use of non-recombinant spores of B. subtilis as a delivery system for mucosal immunizations. The non-recombinant display is based on the adsorption of heterologous molecules on the spore surface without the need of genetic manipulations, thus avoiding all concerns about the use and environmental release of genetically modified microorganisms. In addition, adsorbed molecules are stabilized and protected by the interaction with the spore, suggesting that this system could reduce the rapid degradation of the antigen, often observed with other delivery systems and identified as a major drawback of mucosal vaccines.