Diabetes and Epilepsy in Children and Adolescents

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• 作者：M. Loredana Marcovecchio (1) (2)
  Marianna Immacolata Petrosino (1)
  Francesco Chiarelli (1) (2)
  
  1. Department of Paediatrics ; University of Chieti ; via dei Vestini 5 ; 66100 ; Chieti ; Italy
  2. Center of Excellence on Aging ; 鈥淕. D鈥橝nnunzio鈥?University Foundation ; University of Chieti ; Chieti ; Italy
  
• 关键词：Type 1 diabetes ; Epilepsy ; Seizures ; Children ; Adolescents ; Autoantibodies ; GADAs ; Hypoglycemia ; Hyperglycemia
• 刊名：Current Diabetes Reports
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：15
• 期：4
• 全文大小：394 KB
• 参考文献：Diagnosis and classification of diabetes mellitus. Diabetes Care 37: pp. S81-90 CrossRef
  1. Atkinson, MA, Eisenbarth, GS, Michels, AW (2014) Type 1 diabetes. Lancet 383: pp. 69-82 CrossRef
  2. (IDF) IDF. 21 June 2014. Available from: http://www.idf.org/sites/default/files/EN_6E_Atlas_Full_0.pdf.
  3. Kordonouri, O, Klingensmith, G, Knip, M, Holl, RW, Menon, PSN, Aanstoot, HJ (2014) Other complications and diabetes-associated conditions in children and adolescents. Pediatr Diabetes 15: pp. 270-8 CrossRef
  4. Mosh猫 SL, Perucca E, Ryvlin P, Tomson T. Epilepsy: new advances. Lancet. 2014. / Recent review on new advances on epilepsy.
  5. Fisher, RS, Acevedo, C, Arzimanoglou, A (2014) ILAE official report: a practical clinical definition of epilepsy. Epilepsia 55: pp. 475-82 CrossRef
  6. Martinez, C, Sullivan, T, Hauser, WA (2009) Prevalence of acute repetitive seizures (ARS) in the United Kingdom. Epilepsy Res 87: pp. 137-43 CrossRef
  7. Ottman, R, Lipton, RB, Ettinger, AB (2011) Comorbidities of epilepsy: results from the Epilepsy Comorbidities and Health (EPIC) survey. Epilepsia 52: pp. 308-15
  8. Banerjee, PN, Filippi, D, Allen Hauser, W (2009) The descriptive epidemiology of epilepsy鈥攁 review. Epilepsy Res 85: pp. 31-45 CrossRef
  9. Waaler, PE, Blom, BH, Skeidsvoll, H, Mykletum, A (2000) Prevalence, classification and severity of epilepsy in children in Western Norway. Epilepsia 41: pp. 802-10 CrossRef
  10. Larsson, K, Eeg-Olofsson, O (2006) A population based study of epilepsy in children from a Swedish county. Eur J Paediatr Neurol 10: pp. 107-13 CrossRef
  11. Luengo, A, Parra, J, Colas, J (2001) Prevalence of epilepsy in northeast Madrid. J Neurol 248: pp. 762-7 CrossRef
  12. Rocca, WA, Savettiere, G, Andreson, DW (2001) Door to door prevalence survey of epilepsy in three Sicilian municipalities. Neuroepidemiology 20: pp. 237-41 CrossRef
  13. Cowan, LD (2002) The epidemiology of the epilepsies in children. Ment Retard Dev Disabil Res Rev 8: pp. 171-81 CrossRef
  14. Hanly, JG, Urowitz, MB, Su, L (2012) Seizure disorders in systemic lupus erythematosus results from an international, prospective, inception cohort study. Ann Rheum Dis 71: pp. 1502-9 CrossRef
  15. Appenzeller, S, Cendes, F, Costallat, LT (2004) Epileptic seizures in systemic lupus erythematosus. Neurology 63: pp. 1808-12 CrossRef
  16. Andrade, RM, Alarc贸n, GS, Gonz谩lez, LA (2008) Seizures in patients with systemic lupus erythematosus: data from LUMINA, a multiethnic cohort (LUMINA LIV). Ann Rheum Dis 67: pp. 829-34 CrossRef
  17. Shoenfeld, Y, Lev, S, Blatt, I, Blank, M (2004) Features associated with epilepsy in the antiphospholipid syndrome. J Rheumatol 31: pp. 1344-8
  18. Cervera, R, Piette, JC, Font, J (2002) Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum 46: pp. 1019-27 CrossRef
  19. Vincent, A, Irani, SR, Lang, B (2011) Potentially pathogenic autoantibodies associated with epilepsy and encephalitis in children and adults. Epilepsia 52: pp. 8-11 CrossRef
  20. Ong, MS, Kohane, IS, Cai, T, Gorman, MP, Mandl, KD (2014) Population-level evidence for an autoimmune etiology of epilepsy. JAMA Neurol 71: pp. 569-74 CrossRef
  21. Vincent, A, Crino, PB (2011) Systemic and neurologic autoimmune disorders associated with seizures or epilepsy. Epilepsia 52: pp. 12-7 CrossRef
  22. McCorry, D, Nicolson, A, Smith, D, Marson, A, Feltbower, RG, Chadwick, DW (2006) An association between type 1 diabetes and idiopathic generalized epilepsy. Ann Neurol 59: pp. 204-6 CrossRef
  23. O鈥機onnell, MA, Harvey, AS, Mackay, MT, Cameron, FJ (2008) Does epilepsy occur more frequently in children with type 1 diabetes. J Paediatr Child Health 44: pp. 586-9 CrossRef
  24. Schober, E, Otto, KP, Dost, A, Jorch, N, Holl, R (2012) German/Austrian DPV, initiative and the BMBF competence network diabetes. Association of epilepsy and type 1 diabetes mellitus in children and adolescents: is there an increased risk for diabetic ketoacidosis?. J Pediatr 160: pp. 662-6 CrossRef
  25. Ramakrishnan, R, Appleton, R (2012) Study of prevalence of epilepsy in children with type 1 diabetes mellitus. Seizure 21: pp. 292-4 CrossRef
  26. Maccario, M, Messis, CP, Vastola, EF (1965) Focal seizures as a manifestation of hyperglycemia without ketoacidosis. A report of seven cases with review of the literature. Neurology 15: pp. 195-206 CrossRef
  27. Whiting, S, Camfield, P, Arab, D, Salisbury, S (1997) Insulin-dependent diabetes mellitus presenting in children as frequent, medically unresponsive, partial seizures. J Child Neurol 12: pp. 178-80 CrossRef
  28. Sabharwal, RK, Gupta, M, Sharma, D, Puri, V (1989) Juvenile diabetes manifesting as epilepsia partialis continua. J Assoc Physicians India 37: pp. 603-4
  29. Olson JA, Olson DM, Sandborg C, Alexander S, Buckingham B. Type 1 diabetes mellitus and epilepsy partialis continua in a 6-year-old boy with elevated anti-GAD65 antibodies. Pediatrics. 2002;109:E50.
  30. Mukherjee, V, Mukherjee, A, Mukherjee, A, Halder, A (2007) Type I diabetes mellitus in a child presenting with epilepsy partialis continua. J Indian Med Assoc 105: pp. 340-2
  31. Baglietto, MG, Mancardi, MM, Giannattasio, A (2009) Epilepsia partialis continua in type 1 diabetes: evolution into epileptic encephalopathy with continuous spike-waves during slow sleep. Neurol Sci 30: pp. 509-12 CrossRef
  32. Mancardi, MM, Striano, P, Giannattasio, A (2010) Type I diabetes and epilepsy: more than a casual relationship?. Epilepsia 51: pp. 320-1 CrossRef
  33. Shinnar, S, Pellock, JM (2002) Update on the epidemiology and prognosis of pediatric epilepsy. J Child Neurol 17: pp. S4-17 CrossRef
  34. Hung, WL, Hsieh, PF, Lee, YC, Chang, MH (2010) Occipital lobe seizures related to marked elevation of hemoglobin A1C: report of two cases. Seizure 19: pp. 359-62 CrossRef
  35. Wang, CP, Hsieh, PF, Chen, CC (2005) Hyperglycemia with occipital seizures: images and visual evoked potentials. Epilepsia 46: pp. 1140-4 CrossRef
  36. Tiras, R, Mutlu, A, Ozben, S, Aydemir, T, Ozer, F (2009) Forced eye closure-induced reflex seizure and non-ketotic hyperglycemia. Ann Saudi Med 29: pp. 313-5 CrossRef
  37. Siddiqi, ZA, VanLandingham, KE, Husain, AM (2002) Reflex seizures and non-ketotic hyperglycemia: an unresolved issue. Seizure 11: pp. 63-6 CrossRef
  38. Caietta, E, Halbert, C, L茅pine, A (2012) Association of type 1 diabetes mellitus and epilepsy in children. A cohort of 10 cases. Arch Pediatr 19: pp. 9-16 CrossRef
  39. Cotellessa, M, Barbieri, P, Mazzella, M, Bonassi, S, Minicucci, L, Lorini, R (2003) High incidence of childhood type 1 diabetes in Liguria, Italy, from 1989 to 1998. Diabetes Care 26: pp. 1786-9 CrossRef
  40. Duncan, JS, Sander, JW, Sisodiya, SM, Walker, MC (2006) Adult epilepsy. Lancet 367: pp. 1087-100 CrossRef
  41. Hirsch, LJ, Hauser, WA (2004) Can sudden unexplained death in epilepsy be prevented?. Lancet 364: pp. 2157-8 CrossRef
  42. Surges, R, Thijs, RD, Tan, HL, Sander, JW (2009) Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms. Nat Rev Neurol 5: pp. 492-504 CrossRef
  43. Yun, C, Xuefeng, W (2013) Association between seizures and diabetes mellitus: a comprehensive review of literature. Curr Diabetes Rev 9: pp. 350-4 CrossRef
  44. Maheandiran, M, Mylvaganam, S, Wu, C (2013) Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality. PLoS One 8: pp. e83168 CrossRef
  45. Schwechter, EM, Vel铆skov谩, J, Vel铆sek, L (2003) Correlation between extracellular glucose and seizure susceptibility in adult rats. Ann Neurol 53: pp. 91-101 CrossRef
  46. Kirchner, A, Vel铆skov谩, J, Vel铆sek, L (2006) Differential effects of low glucose concentrations on seizures and epileptiform activity in vivo and in vitro. Eur J Neurosci 23: pp. 1512-22 CrossRef
  47. Secrest, AM, Becker, DJ, Kelsey, SF, Laporte, RE, Orchard, TJ (2010) Cause-specific mortality trends in a large population-based cohort with long-standing childhood-onset type 1 diabetes. Diabetes 59: pp. 3216-22 CrossRef
  48. Wagner, VM, Rosenbauer, J, Grabert, M, Holl, RW (2008) Severe hypoglycaemia, metabolic control and diabetes management in young children with type 1 diabetes using insulin analogs鈥攁 follow up report of a large multicenter database. Eur J Pediatr 167: pp. 241-2 CrossRef
  49. Katz, ML, Volkening, LK, Anderson, BJ, Laffel, LM (2012) Contemporary rates of severe hypoglycaemia in youth with type 1 diabetes: variability by insulin regimen. Diabet Med 29: pp. 926-32 CrossRef
  50. Lahat, E, Barr, J, Bistritzer, T (1995) Focal epileptic episodes associated with hypoglycemia in children with diabetes. Clin Neurol Neurosurg 97: pp. 314-6 CrossRef
  51. Wayne, EA, Dean, HJ, Booth, F, Tenenbein, M (1990) Focal neurological deficits associated with hypoglycemia in children with diabetes. J Pediatr 117: pp. 575-7 CrossRef
  52. Heller, SR (2002) Abnormalities of the electrocardiogram during hypoglycaemia: the cause of the dead in bed syndrome?. Int J Clin Pract Suppl 129: pp. 27-32
  53. Tokizane, T (1957) Sites of origin of hypoglycemic seizures in the rabbit. AMA Arch Neurol Psychiatr 77: pp. 259-66 CrossRef
  54. Gruetter, R (2003) Glycogen: the forgotten cerebral energy store. J Neurosci Res 74: pp. 179-83 CrossRef
  55. McCall, AL (2004) Cerebral glucose metabolism in diabetes mellitus. Eur J Pharmacol 490: pp. 147-58 CrossRef
  56. Rakhade, SN, Jensen, FE (2009) Epileptogenesis in the immature brain: emerging mechanisms. Nat Rev Neurol 5: pp. 380-91 CrossRef
  57. Yamada, KA, Rensing, N, Izumi, Y (2004) Repetitive hypoglycemia in young rats impairs hippocampal long-term potentiation. Pediatr Res 55: pp. 372-9 CrossRef
  58. Suh, SW, Hamby, AM, Swanson, RA (2007) Hypoglycemia, brain energetics, and hypoglycemic neuronal death. Glia 55: pp. 1280-6 CrossRef
  59. Wolfsdorf, J, Glaser, N, Sperling, MA (2006) Diabetic ketoacidosis in infants, children, and adolescents: a consensus statement from the American Diabetes Association. Diabetes Care 29: pp. 1150-9 CrossRef
  60. Takeoka, M, Holmes, GL, Thiele, E, Bourgeois, BF, Helmers, SL, Duffy, FH (2001) Topiramate and metabolic acidosis in pediatric epilepsy. Epilepsia 42: pp. 387-92 CrossRef
  61. Ko, CH, Kong, CK (2001) Topiramate-induced metabolic acidosis: report of two cases. Dev Med Child Neurol 43: pp. 701-4 CrossRef
  62. Groeper, K, McCann, ME (2005) Topiramate and metabolic acidosis: a case series and review of the literature. Paediatr Anaesth 15: pp. 167-70 CrossRef
  63. Bien, CG, Scheffer, IE (2011) Autoantibodies and epilepsy. Epilepsia 52: pp. 18-22 CrossRef
  64. Striano, P, Errichiello, L, Striano, S (2011) Autoantibodies to glutamic acid decarboxylase in patients with epilepsy: what is their clinical relevance?. Epilepsy Behav 20: pp. 145
  65. Errichiello, L, Perruolo, G, Pascarella, A (2009) Autoantibodies to glutamic acid decarboxylase (GAD) in focal and generalized epilepsy: a study on 233 patients. J Neuroimmunol 211: pp. 120-3 CrossRef
  66. Stagg, CJ, Lang, B, Best, JG (2010) Autoantibodies to glutamic acid decarboxylase in patients with epilepsy are associated with low cortical GABA levels. Epilepsia 51: pp. 1898-901 CrossRef
  67. Piquer, S, Belloni, C, Lampasona, V (2005) Humoral autoimmune responses to glutamic acid decarboxylase have similar target epitopes and subclass that show titer-dependent disease association. Clin Immunol 117: pp. 31-5 CrossRef
  68. Manto, MU, Laute, MA, Aguera, M, Rogemond, V, Pandolfo, M, Honnorat, J (2007) Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases. Ann Neurol 61: pp. 544-51 CrossRef
  69. Vianello, M, Tavolato, B, Giometto, B (2002) Glutamic acid decarboxylase autoantibodies and neurological disorders. Neurol Sci 23: pp. 145-51 CrossRef
  70. Vianello, M, Bisson, G, Dal Maschio, M (2008) Increased spontaneous activity of a network of hippocampal neurons in culture caused by suppression of inhibitory potentials mediated by anti-gad antibodies. Autoimmunity 41: pp. 66-73 CrossRef
  71. Liimatainen, S, Peltola, M, Sabater, L (2010) Clinical significance of glutamic acid decarboxylase antibodies in patients with epilepsy. Epilepsia 51: pp. 760-7 CrossRef
  72. Saiz, A, Blanco, Y, Sabater, L (2008) Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. Brain 131: pp. 2553-63 CrossRef
  73. Giometto, B, Nicolao, P, Macucci, M, Tavolaro, B, Foxon, R, Bottazzo, GF (1998) Temporal-lobe epilepsy associated with glutamic-acid-decarboxylase autoantibodies. Lancet 8: pp. 457 CrossRef
  74. Kanter, IC, Huttner, HB, Staykov, D, Biermann, T, Struffert, T, Kerling, F (2008) Cyclophosphamide for anti-GAD antibody-positive refractory status epilepticus. Epilepsia 49: pp. 914-20 CrossRef
  75. Ito, S, Oguni, H (2011) Ketogenic diet for intractable childhood epilepsy; as an early option as well as a last resort. Brain Nerve 63: pp. 393-400
  76. Hartman, AL, Gasior, M, Vining, EP, Rogawski, MA (2007) The neuropharmacology of the ketogenic diet. Pediatr Neurol 36: pp. 281-92 CrossRef
  77. Keene, DL (2006) A systematic review of the use of the ketogenic diet in childhood epilepsy. Pediatr Neurol 35: pp. 1-5 CrossRef
  78. Levy, R, Cooper, P (2003) Ketogenic diet for epilepsy. Cochrane Database Syst Rev 3:
  79. Kossoff, EH, Zupec-Kania, BA, Amark, PE (2009) Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia 50: pp. 304-17 CrossRef
  80. Henderson, CB, Filloux, FM, Alder, SC, Lyon, JL, Caplin, DA (2006) Efficacy of the ketogenic diet as a treatment option for epilepsy: meta-analysis. J Child Neurol 21: pp. 193-8
  81. Aguirre Castaneda, RL, Mack, KJ, Lteif, A (2012) Successful treatment of type 1 diabetes and seizures with combined ketogenic diet and insulin. Pediatrics 129: pp. e511-4 CrossRef
  82. Aylward, NM, Shah, N, Sellers, EA (2014) The ketogenic diet for the treatment of myoclonic astatic epilepsy in a child with type 1 diabetes mellitus. Can J Diabetes 38: pp. 223 CrossRef
  
• 刊物主题：Diabetes;
• 出版者：Springer US
• ISSN：1539-0829

文摘

Over the last years, there has been an increasing interest in the potential association between type 1 diabetes (T1D) and epilepsy. Both T1D and epilepsy are common conditions in children and adolescents, and therefore, their association might represent simply a coincidence or be related to common underlying mechanisms with a potential causal relationship. Few epidemiological studies have been performed in the pediatric population, and they have reached discordant conclusions, with some studies reporting an increased prevalence of epilepsy in children and adolescents with T1D, whereas others have not confirmed this finding. Several mechanisms could explain the occurrence of epilepsy in young people with T1D, such as metabolic abnormalities (hypo/hyperglycemia) and autoantibodies, along with a genetic predisposition and the presence of brain lesions/damage. Further studies are required to better define whether there is a causal relationship between the two conditions and to understand the underlying mechanisms.