TPM3, a strong prognosis predictor, is involved in malignant progression through MMP family members and EMT-like activators in gliomas

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• 作者：Tao Tao (1) (2)
  Yan Shi (1)
  Dongfeng Han (1)
  Wenkang Luan (1)
  Jin Qian (1) (3)
  Junxia Zhang (1)
  Yingyi Wang (1)
  Yongping You (1)
  Chinese Glioma Cooperative Group (CGCG)
  
• 关键词：TPM3 ; MMP ; 9 ; SNAI1 ; Invasion ; Migration ; EMT ; Survival ; Glioma
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：35
• 期：9
• 页码：9053-9059
• 全文大小：840 KB
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• 作者单位：Tao Tao (1) (2)
  Yan Shi (1)
  Dongfeng Han (1)
  Wenkang Luan (1)
  Jin Qian (1) (3)
  Junxia Zhang (1)
  Yingyi Wang (1)
  Yongping You (1)
  Chinese Glioma Cooperative Group (CGCG)
  
  1. Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
  2. Surgical Research Center, Medical School, Southeast University, Nanjing, 210009, China
  3. Department of Neurosurgery, People鈥檚 Hospital of Xuancheng City, Anhui, 242000, China
  
• ISSN：1423-0380

文摘

Recent studies have shown that many molecular mechanisms, such as the EGFR, AKT, STAT3, and beta-catenin pathways, are involved in glioma. However, the prognosis of the disease remains poor. Explorations of the underlying mechanisms of glioma and identification of effective markers for early diagnosis and accurate prognostication remain important today. In this study, we employed survival analysis to determine that TPM3 overexpression was significantly associated with high-grade gliomas and higher mortality. Using microarray combined with Pearson correlation analysis, we found that TPM3 was positively correlated with the expression of MMP family members and EMT-like activators. Reduction of TPM3 (via TPM3-siRNA) inhibited cellular invasion and migration and decreased MMP-9 and SNAI1 levels in glioma cells. To the best of our knowledge, our work is the first to show that TPM3 plays a critical role in the progression of gliomas and provides novel insights into the key roles of MMP family members and EMT-like activators that mediate TPM3 functional signaling for glioma regulation.