Mod(mdg4)-58.0, the product of m class="a-plus-plus">modm>(m class="a-plus-plus">mdg4m>) locus, directly interacts with kermit protein of m class="a-plus-plus">Drosophila melanogasterm>

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• 作者：A. K. Golovnin ; M. V. Kostyuchenko ; P. G. Georgiev…
• 关键词：Mod(mdg4) ; Kermit (dGIPC) ; Drosophila ; protein–protein interactions ; yeast two ; hybrid system ; co ; immunoprecipitation of proteins ; cell immunostaining
• 刊名：Russian Journal of Genetics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：53
• 期：1
• 页码：153-156
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics;
• 出版者：Pleiades Publishing
• ISSN：1608-3369
• 卷排序：53

文摘

The experiments in a yeast two-hybrid system, on co-immunoprecipitation of proteins from the D. melanogaster embryonic cell lysates, and on cell immunostaining have shown for the first time that the product of mod(mdg4) locus, Mod (mdg4)-58.0 (isoform C), directly interacts with Kermit protein (dGIPC). Kermit protein plays an important role in locomotor activity, polarization of the cells within the plane of the epithelium at the early stages of development, transfer of intercellular signals, and determining the longevity of Drosophila. These data expand the understanding of the role of Mod(mdg4)-58.0 protein in the eukaryotic cell activity.