Non-stroke Central Neurologic Manifestations in Antiphospholipid Syndrome
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  • 作者：Cécile M. Yelnik ; Elizabeth Kozora ; Simone Appenzeller
  • 关键词：Antiphospholipid syndrome (APS) ; Antiphospholipid antibody ; Non ; thrombotic manifestations ; Neurological manifestations ; Systemic lupus erythematosus (SLE) ; Autoimmunity
  • 刊名：Current Rheumatology Reports
  • 出版年：2016
  • 出版时间：February 2016
  • 年：2016
  • 卷：18
  • 期：2
  • 全文大小：349 KB
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  • 作者单位：Cécile M. Yelnik (1) (2)
    Elizabeth Kozora (2) (3) (4)
    Simone Appenzeller (5)

    1. Internal Medicine Department, UFR Medicine, University of Lille, Lille, France
    2. Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY, USA
    3. Department of Medicine, National Jewish Health, Denver, CO, USA
    4. Departments of Psychiatry and Neurology, University of Colorado School of Medicine, Aurora, CO, USA
    5. Department of Medicine, Faculty of Medical Science, State University of Campinas, Campinas, Brazil
  • 刊物主题：Rheumatology;
  • 出版者：Springer US
  • ISSN：1534-6307
    • 文摘
    Thrombotic manifestations of antiphospholipid syndrome (APS) are well known, and various non-stroke neuro-psychiatric manifestations (NPMs) have also been consistently described, but their place in APS remains unclear. Some syndromes, such as migraine or cognitive dysfunction, are frequently described in APS, whereas others, like seizure, multiple sclerosis-like symptoms, transverse myelitis, movement disorders, or psychiatric symptoms, are rarely found. Overlap with other autoimmune diseases, in particular with systemic lupus erythematosus, the lack of large sample size prospective studies, and discrepancies in antiphospholipid antibody (aPL) determinations complicate the study of the relationship between those disorders and aPL/APS. This review article aimed to summarize updated data on pathophysiologic, epidemiologic, and radiologic findings about non-stroke NPM described in primary APS and aPL-positive patients without overlap of other autoimmune diseases.

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