Synthesis and Characterization of Poly(2-hydroxyethylmethacrylate) Contact Lenses Containing Chitosan Nanoparticles as an Ocular Delivery System for Dexamethasone Sodium Phosphate

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• 作者：Gautam Behl ; Javed Iqbal ; Niall J. O’Reilly ; Peter McLoughlin…
• 刊名：Pharmaceutical Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：33
• 期：7
• 页码：1638-1648
• 全文大小：1,584 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Pharmacy
  Biochemistry
  Medical Law
  Biomedical Engineering
  
• 出版者：Springer Netherlands
• ISSN：1573-904X
• 卷排序：33

文摘

PurposeDexamethasone sodium phosphate (DXP) is an anti-inflammatory drug commonly used to treat acute and chronic ocular diseases. It is routinely delivered using eye-drops, where typically only 5% of the drug penetrates the corneal epithelium. The bioavailability of such ophthalmic drugs can be enhanced significantly using contact lenses incorporating drug-loaded nanoparticles (NPs).