A comparative study of faecal occult blood kits in a colorectal cancer screening program in a cohort of healthy construction workers

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• 作者：M. Shuhaibar (1)
  C. Walsh (2)
  F. Lindsay (1)
  N. Lee (1)
  P. Walsh (3)
  P. O’Gorman (3)
  G. Boran (3)
  R. McLoughlin (1)
  A. Qasim (1)
  N. Breslin (1)
  B. Ryan (1)
  H. O’Connor (1)
  C. O’Morain (1)
  
• 关键词：Colorectal cancer (CRC) ; Screening ; FIT (faecal immunochemical testing) ; gFOBT (gauaic faecal occult blood test) ; Adenomas ; Uptake rates ; Outcomes
• 刊名：Irish Journal of Medical Science
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：180
• 期：1
• 页码：103-108
• 全文大小：209KB
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• 作者单位：M. Shuhaibar (1)
  C. Walsh (2)
  F. Lindsay (1)
  N. Lee (1)
  P. Walsh (3)
  P. O’Gorman (3)
  G. Boran (3)
  R. McLoughlin (1)
  A. Qasim (1)
  N. Breslin (1)
  B. Ryan (1)
  H. O’Connor (1)
  C. O’Morain (1)
  
  1. Department of Gastroenterology/Clinical Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, The Adelaide and Meath Hospital, Dublin Incorporating The National Children’s Hospital, Tallaght, Dublin, Ireland
  2. Department of Statistics, Trinity College Dublin, The Adelaide and Meath Hospital, Dublin Incorporating The National Children’s Hospital, Tallaght, Dublin, Ireland
  3. Department of Clinical Chemistry, Trinity College Dublin, The Adelaide and Meath Hospital, Dublin Incorporating The National Children’s Hospital, Tallaght, Dublin, Ireland
  

文摘

Background The incidence of colorectal cancer (CRC) has been increasing. We evaluated uptake rates and outcomes of faecal immunochemical test (FIT) and Guaiac test (gFOBT) kits as part of a two-step CRC screening. Methods A 3-year CRC screening program for a defined population of construction workers was conducted. Those satisfying the inclusion criteria were provided with gFOBT or FIT kits. Individuals testing positive were invited for a colonoscopy. Results A total of 909 faecal testing kits were distributed. Age range was 53-0?years. Compliance rate was higher for FIT (58.3%) as compared to gFOBT (46.7%) (p?=?0.0006). FIT detected adenomatous polyps and CRC in 37.5 and 25%, respectively, whereas; gFOBT detected 23.5 and 18%. Colonoscopies were normal in 53 and 25% tested positive by gFOBT and FIT, respectively (p?=?0.016). Conclusion The FIT was more cost-effective when compared with gFOBT with higher return rate, sensitivity and specificity. A comparative study of faecal occult blood kits in a CRC screening program in a healthy cohort of construction workers.