Mechanosensory molecules and circuits in C. elegans
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- 作者：William R. Schafer (1)
- 关键词：Mechanosensation ; C. elegans ; Nociceptor ; Proprioception ; TRP channel ; Neural circuits
- 刊名：Pflügers Archiv - European Journal of Physiology
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：467
- 期：1
- 页码：39-48
- 全文大小：406 KB
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1. Cell Biology Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK - 刊物主题：Human Physiology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-2013
文摘
Mechanosensory neurons, whose activity is controlled by mechanical force, underlie the senses of touch, hearing, and proprioception, yet despite their importance, the molecular basis of mechanotransduction is poorly understood. Genetic studies in Caenorhabditis elegans have provided a useful approach for identifying potential components of mechanotransduction complexes that might be conserved in more complex organisms. This review describes the mechanosensory systems of C. elegans, including the sensory neurons and circuitry involved in body touch, nose touch, and proprioception. In addition, the roles of genes encoding known and potential mechanosensory receptors, including members of the broadly conserved transient receptor potential (TRP) and degerin/epithelial Na+ channel (DEG/ENaC) channel families, are discussed.