The abundance of fecal Faecalibacterium prausnitzii in relation to obesity and gender in Chinese adults

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• 作者：Jie Feng (1) (2)
  Huang Tang (1) (2)
  Min Li (2) (3)
  Xiaoyan Pang (2)
  Linghua Wang (2)
  Menghui Zhang (2)
  Yufeng Zhao (1)
  Xiaojun Zhang (2)
  Jian Shen (1)
  
• 关键词：Faecalibacterium prausnitzii ; Obesity ; Gender ; Fecal microbiota
• 刊名：Archives of Microbiology
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：196
• 期：1
• 页码：73-77
• 全文大小：310 KB
• 作者单位：Jie Feng (1) (2)
  Huang Tang (1) (2)
  Min Li (2) (3)
  Xiaoyan Pang (2)
  Linghua Wang (2)
  Menghui Zhang (2)
  Yufeng Zhao (1)
  Xiaojun Zhang (2)
  Jian Shen (1)
  
  1. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China
  2. State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China
  3. Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 363 Bevier Hall, M/C 182, 905 South Goodwin Ave., Urbana, IL, 61801, USA
  
• ISSN：1432-072X

文摘

The influence of gender and obesity on the abundance of human colonic Feacalibacterium prausnitzii is currently unclear. We collected fecal samples from 54 obese and 54 sex- and age-matched normal-weight Chinese adults and quantified the fecal F. prausnitzii as percentage of 16S rRNA gene copies of F. prausnitzii accounting to that of total gut bacteria with quantitative PCR. The fecal F. prausnitzii amount was not significantly different between obese and lean subjects. Men possessed significantly lower level of fecal F. prausnitzii than women, and the significant and positive correlation of fecal F. prausnitzii quantity with fasting glucose level was observed in men, not in women. Our results suggest that the gender effect, in addition to other factors including the geographic location, ethnicity, diet and gut transit times of study subjects, has to be considered when studying the relationship between gut F. prausnitzii and diseases.