Topotecan Can Compensate for Protracted Radiation Treatment Time Effects in High Grade Glioma Xenografts*
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- 作者：Sophie Pinel ; Pascal Chastagner ; Jean-Louis Merlin ; Christian Marchal ; Alphonse Taghian and Muriel Barberi-Heyob
- 关键词：concomitant chemoradiation ; human malignant glioma xenografts ; overall treatment time ; radiotherapy ; topotecan
- 刊名：Journal of Neuro-Oncology
- 出版年：2006
- 出版时间：January 2006
- 年：2006
- 卷：76
- 期：1
- 页码：31-38
- 全文大小：258 KB
文摘
Purpose: Several studies reported that prolongation of overall treatment time of fractionated radiotherapy reduces the chance of tumor control. In the present study, we hypothesize that combining topotecan with irradiation could compensate for this detrimental time effect on the radioresponse. Therefore, we investigated the efficiency of different schedules of topotecan (TPT), radiotherapy (RT) or concomitant combination TPT + RT. Methods and Materials: Experiments were performed in two human high-grade glioma xenograft models (U87 and GBM Nan1). TPT and RT were delivered at a total dose of 3 mg/kg and 40 Gy, respectively. For the TPT + RT groups, TPT was injected 5 min before radiation. Total radiation doses were delivered in 5, 10, 20, or 30 fractions over 1, 2, 4, or 6 weeks, respectively. The efficiency of TPT, RT, and TPT + RT was evaluated by tumor growth delay (TGD).