Differential metabolic responses in three life stages of mussels Mytilus galloprovincialis exposed to cadmium

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• 作者：Huifeng Wu ; Lanlan Xu ; Deliang Yu ; Chenglong Ji
• 关键词：Mytilus galloprovincialis ; Cadmium ; Toxicological effects ; NMR ; Metabolomics
• 刊名：Ecotoxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：26
• 期：1
• 页码：74-80
• 全文大小：
• 刊物类别：Earth and Environmental Science
• 刊物主题：Environment, general; Ecotoxicology; Ecology; Environmental Management;
• 出版者：Springer US
• ISSN：1573-3017
• 卷排序：26

文摘

Cadmium (Cd) is one of the most important metal contaminants in the Bohai Sea. In this work, NMR-based metabolomics was used to investigate the toxicological effects of Cd at an environmentally relevant concentration (50 µg L−1) in three different life stages (D-shape larval, juvenile and adult) of mussels Mytilus galloprovincialis. Results indicated that the D-shape larval mussel was the most sensitive life stage to Cd. The significantly different metabolic profiles meant that Cd induced differential toxicological effects in three life stages of mussels. Basically, Cd caused osmotic stress in all the three life stages via different metabolic pathways. Cd exposure reduced the anaerobiosis in D-shape larval mussels and disturbed lipid metabolism in juvenile mussels, respectively. Compared with the D-shape larval and juvenile mussels, the adult mussels reduced energy consumption to deal with Cd stress.