Sickle Cell Trait from a Metabolic, Renal, and Vascular Perspective: Linking History, Knowledge, and Health

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• 作者：Caroline K. Thoreson ; Michelle Y. O鈥機onnor…
• 关键词：Sickle cell trait ; Newborn screening ; Exercise ; related sudden death ; Exertional sickling ; Hematuria ; Stroke
• 刊名：Journal of Racial and Ethnic Health Disparities
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：2
• 期：3
• 页码：330-335
• 全文大小：189KB
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• 作者单位：Caroline K. Thoreson (1)
  Michelle Y. O鈥機onnor (1)
  Madia Ricks (1)
  Stephanie T. Chung (1)
  Anne E. Sumner (1)
  
  1. Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, Bld 10-CRC, Rm 6-5940, MSC 1612 9000 Rockville Pike, Bethesda, MD, 20892-1612, USA
  
• 刊物类别：Medicine/Public Health, general; Epidemiology; Quality of Life Research; Social Structure, Social In
• 刊物主题：Medicine/Public Health, general; Epidemiology; Quality of Life Research; Social Structure, Social Inequality;
• 出版者：Springer International Publishing
• ISSN：2196-8837

文摘

Sickle cell trait (SCT) is at the intersection of genetics, social policy, and medicine. SCT occurs in three-hundred million people worldwide and in approximately 8 % of African-Americans. There has been great debate about the influence of SCT on health. Yet data exist, albeit controversial, which suggest that SCT is associated with metabolic derangements that can lead to sudden death after vigorous physical activity, renal dysfunction, thromboembolic events, and stroke. In addition, it has even been postulated that SCT might enhance the vascular complications of diabetes. This review focuses on (a) the scientific breakthroughs that led to the discovery of hemoglobin S, sickle cell disease, and SCT, (b) the history of screening programs in the United States, (c) the incidence and etiology of exercise-related sudden death in military personnel and athletes with SCT, and (d) the data examining the potential chronic disease consequences of SCT from a metabolic, renal, and vascular perspective. Keywords Sickle cell trait Newborn screening Exercise-related sudden death Exertional sickling Hematuria Stroke