Influence of pH, temperature, and alternating magnetic field on drug release from Keggin-type heteropoly acid encapsulated in iron–carboxylate nanoscale metal–organic framework

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• 作者：Ezzat Rafiee ; Narges Nobakht ; Leila Behbood
• 关键词：Drug delivery ; Epirubicin ; Heteropoly acid ; Metal–organic framework ; Nanocomposite
• 刊名：Research on Chemical Intermediates
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：2
• 页码：951-969
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Catalysis; Physical Chemistry; Inorganic Chemistry;
• 出版者：Springer Netherlands
• ISSN：1568-5675
• 卷排序：43

文摘

Nanosized mesoporous iron–carboxylate [MIL-100(Fe)]-encapsulated Keggin phosphotungstic acid H₃PW₁₂O₄₀ (PW) was fabricated via an environmentally friendly hydrothermal synthesis method and characterized by Fourier-transform infrared spectroscopy, high-resolution transmission electron microscopy, field-emission scanning electron microscopy, particle size analysis, and powder X-ray diffraction analysis. The metal content was analyzed by energy-dispersive X-ray spectroscopy. PW@MIL-100(Fe) was then studied as a drug delivery system, exhibiting the ability to entrap epirubicin (EPI) as a model drug. The drug loading efficiency, drug content, and drug release behavior of PW@MIL-100(Fe), MIL-100(Fe), and PW@HKUST-1 [where HKUST-1 is Cu₃(BTC)₂ with BTC = benzene-1,3,5-tricarboxylic acid] were also studied. The results indicate that PW@MIL-100(Fe) possessed high adsorption capacity (28 wt%) and loading efficiency (91.6 %) for epirubicin. Drug release from PW@MIL-100(Fe) at different pH values (5, 5.8, 6.5, and 7.4) and temperatures and with an alternative magnetic field was investigated, and the stability of the nanocarrier after EPI release was studied by Fourier-transform infrared spectroscopy and field-emission scanning electron microscopy. Cellular toxicity was also investigated. The results show that this is a good candidate as a future drug nanocarrier.