Emerging Trends in Heart Valve Engineering: Part I. Solutions for Future

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• 作者：Arash Kheradvar (1) (2)
  Elliott M. Groves (1) (2)
  Lakshmi P. Dasi (3)
  S. Hamed Alavi (1)
  Robert Tranquillo (4)
  K. Jane Grande-Allen (5)
  Craig A. Simmons (6) (7)
  Boyce Griffith (8) (9)
  Ahmad Falahatpisheh (1)
  Craig J. Goergen (10)
  Mohammad R. K. Mofrad (11)
  Frank Baaijens (12)
  Stephen H. Little (13)
  Suncica Canic (14)
  
  1. Department of Biomedical Engineering ; The Edwards Lifesciences Center for Advanced Cardiovascular Technology ; University of California ; Irvine ; 2410 Engineering Hall ; Irvine ; CA ; 92697-2730 ; USA
  2. Department of Internal Medicine ; Division of聽Cardiology ; University of California ; Irvine School of Medicine ; Irvine ; CA ; USA
  3. Department of Mechanical聽Engineering ; School of Biomedical Engineering ; Colorado State University ; Fort Collins ; CO ; USA
  4. Department of Biomedical Engineering ; University of Minnesota ; Minneapolis ; MN ; USA
  5. Department of Bioengineering ; Rice University ; Houston ; TX ; USA
  6. Department of Mechanical & Industrial Engineering ; University of Toronto ; Toronto ; ON ; Canada
  7. Institute of聽Biomaterials & Biomedical Engineering ; University of Toronto ; Toronto ; ON ; Canada
  8. Department of Mathematics ; Center for Interdisciplinary Applied Mathematics ; University of North Carolina at Chapel Hill ; Chapel Hill ; NC ; USA
  9. McAllister Heart Institute ; University of North Carolina聽at Chapel Hill School of Medicine ; Chapel Hill ; NC ; USA
  10. Weldon School of Biomedical Engineering ; Purdue University ; West Lafayette ; IN ; USA
  11. Department of Bioengineering and Mechanical Engineering ; University of聽California ; Berkeley ; Berkeley ; CA ; USA
  12. Department of Biomedical Engineering ; Eindhoven University of聽Technology ; Eindhoven ; The Netherlands
  13. Houston Methodist DeBakey Heart & Vascular Center ; Houston ; TX ; USA
  14. Department of Mathematics ; University of Houston ; Houston ; TX ; USA
  
• 关键词：Heart valve engineering ; Tissue engineered heart valves ; Polymeric heart valves
• 刊名：Annals of Biomedical Engineering
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：43
• 期：4
• 页码：833-843
• 全文大小：840 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  Biomedical Engineering
  Biophysics and Biomedical Physics
  Mechanics
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-9686

文摘

As the first section of a multi-part review series, this section provides an overview of the ongoing research and development aimed at fabricating novel heart valve replacements beyond what is currently available for patients. Here we discuss heart valve replacement options that involve a biological component or process for creation, either in vitro or in vivo (tissue-engineered heart valves), and heart valves that are fabricated from polymeric material that are considered permanent inert materials that may suffice for adults where growth is not required. Polymeric materials provide opportunities for cost-effective heart valves that can be more easily manufactured and can be easily integrated with artificial heart and ventricular assist device technologies. Tissue engineered heart valves show promise as a regenerative patient specific model that could be the future of all valve replacement. Because tissue-engineered heart valves depend on cells for their creation, understanding how cells sense and respond to chemical and physical stimuli in their microenvironment is critical and therefore, is also reviewed.