Clinical isolates of Candida albicans, Candida tropicalis, and Candida krusei have different susceptibilities to Co(II) and Cu(II) complexes of 1,10-phenanthroline

详细信息    查看全文

• 作者：Amanda E. Hoffman (1)
  Leann Miles (1)
  Tiffany J. Greenfield (1)
  Carolyn Shoen (2)
  Michelle DeStefano (2)
  Michael Cynamon (2)
  Robert P. Doyle (1)
  
  1. Department of Chemistry ; Syracuse University ; Syracuse ; NY ; 13244 ; USA
  2. Veterans Affairs Medical Center ; 800 Irving Avenue ; Syracuse ; NY ; 13210 ; USA
  
• 关键词：Candida ; Cobalt ; Copper ; MIC90 ; MIC50 ; Pyrophosphate
• 刊名：Biometals
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：28
• 期：2
• 页码：415-423
• 全文大小：298 KB
• 参考文献：1. Bross, J, Talbot, GH, Maislin, G, Hurwitz, S, Strom, BL (1989) Risk factors for nosocomial candidemia: a case-control study in adults without leukemia. Am J Med 87: pp. 614-620 CrossRef
  2. Brown, GD, Denning, DW, Levitz, SM (2012) Tackling human fungal infections. Science 336: pp. 647 CrossRef
  3. Brunke, S, Hube, B (2013) Two unlike cousins: candida albicans and C. glabrata infection strategies. Cell Microbiol 15: pp. 701-708 CrossRef
  4. Butler, G (2009) Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature 459: pp. 657-662 CrossRef
  5. Calderone, RA (2002) Candida and Candidiasis. ASM Press, Washington, DC
  6. Dupont, CL, Grass, G, Rensing, C (2011) Copper toxicity and the origin of bacterial resistance鈥搉ew insights and applications. Metallomics 3: pp. 1109-1118 CrossRef
  7. Gonzalez, GM, Elizondo, M, Ayala, J (2008) Trends in species distribution and susceptibility of bloodstream isolates of Candida collected in Monterrey, Mexico, to seven antifungal agents: results of a 3-year (2004 to 2007) surveillance study. J Clin Microbiol 46: pp. 2902-2905 CrossRef
  8. Graf, N, Lippard, SJ (2012) Redox activation of metal-based prodrugs as a strategy for drug delivery. Adv Drug Deliv Rev 64: pp. 993-1004 CrossRef
  9. Guo, Z, Sadler, PJ (1999) Metals in Medicine. Angew Chem Int Ed 38: pp. 1512-1531 CrossRef
  10. Hagerty, JA, Ortiz, J, Reich, D, Manzarbeitia, C (2003) Fungal infections in solid organ transplant patients. Surg Infect 4: pp. 263-271 CrossRef
  11. Hamer, DH, Thiele, DJ, Lemontt, JE (1985) Function and autoregulation of yeast copperthionein. Science 228: pp. 685-690 CrossRef
  12. Heeres, J, Meerpoel, L, Lewi, P (2010) Conazoles. Molecules 15: pp. 4129-4188 CrossRef
  13. Heffern, MC, Yamamoto, N, Holbrook, RJ, Eckermann, AL, Meade, TJ (2013) Cobalt derivatives as promising therapeutic agents. Curr Opin Chem Biol 17: pp. 189-196 CrossRef
  14. Hoffman, AE, DeStefano, M, Shoen, C, Gopinath, K, Warner, DF, Cynamon, M, Doyle, RP (2013) Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacterium tuberculosis. Eur J Med Chem 70: pp. 589-593 CrossRef
  15. Ikotun, OF, Ouellette, W, Lloret, F, Kruger, PE, Julve, M, Doyle, RP (2008) Synthesis, characterization, thermal and magnetic characterization of a pyrophosphate bridged cobalt(II) complex. Eur J Inorg Chem 17: pp. 2691-2697 CrossRef
  16. Ikotun, OF, Higbee, EM, Ouellette, W, Doyle, RP (2009) Pyrophosphate-bridged complexes with picomolar toxicity. J Inorg Biochem 103: pp. 1254-1264 CrossRef
  17. Rex, JH (2008) Approved standard Reference method for broth dilution antifungal susceptibility testing of yeasts M27-A3. Clinical and Laboratory Standards Institute, Wayne
  18. Karabinis, A, Hill, C, Leclercq, B, Tancrede, C, Baume, D, Andremont, A (1988) Risk factors for candidemia in cancer patients: a case-control study. J Clin Microbiol 26: pp. 429-432
  19. Kauffman, CA (2000) Prospective multicenter surveillance study of funguria in hospitalized patients. The National Institute for Allergy and Infectious Diseases (NIAID) Mycoses Study Group. Clin Infect Dis 30: pp. 14-18 CrossRef
  20. Kojic, EM, Darouiche, RO (2004) Candida infections of medical devices. Clin Microbiol Rev 17: pp. 255-267 CrossRef
  21. Kullberg, BJ, Oude Lashof, AM (2002) Epidemiology of opportunistic invasive mycoses. Eur J Med Res 7: pp. 183-191
  22. Lass-Fl枚rl, C (2009) The changing face of epidemiology of invasive fungal disease in Europe. Mycoses 52: pp. 197-205 CrossRef
  23. Lepak, A, Andes, D (2011) Fungal sepsis: optimizing antifungal therapy in the critical care setting. Crit Care Clin 27: pp. 123-147 CrossRef
  24. Lu, LP, Qin, SD, Yang, P, Zhu, ML (2004) Chlorobis(1,10-phenanthroline)copper(II) chloride methanol solvate 4.5-hydrate. Acta Crystallogr E 60: pp. M574-M576 CrossRef
  25. Manzano-Gayosso, P, Hernandez-Hernandez, F, Zavala-Velasquez, N, Mendez-Tovar, LJ, Naquid-Narvaez, JM, Torres-Rodriguez, JM, Lopez-Martinez, R (2008) Candiduria in type 2 diabetes mellitus patients and its clinical significance. Candida spp. antifungal susceptibility. Rev Med Inst Mex Seguro Soc 46: pp. 603-610
  26. Marr, KA, Seidel, K, White, TC, Bowden, RA (2000) Candidemia in allogeneic blood and marrow transplant recipients: evolution of risk factors after the adoption of prophylactic fluconazole. J Infect Dis 181: pp. 309-316 CrossRef
  27. Marvin, ME, Williams, PH, Cashmore, AM (2003) The Candida albicans CTR1 gene encodes a functional copper transporter. Microbiology 149: pp. 1461-1474 CrossRef
  28. Richet, HM, Andremont, A, Tancrede, C, Pico, JL, Jarvis, WR (1991) Risk factors for candidemia in patients with acute lymphocytic leukemia. Rev Infect Dis 13: pp. 211-215 CrossRef
  29. Riggle, PJ, Kumamoto, CA (2000) Role of a Candida albicans P1-type ATPase in resistance to copper and silver ion toxicity. J Bacteriol 182: pp. 4899-4905 CrossRef
  30. Ronconi, L, Sadler, PJ (2007) Using coordination chemistry to design new medicines. Coord Chem Rev 251: pp. 1633-1648 CrossRef
  31. Ruan, SY, Hsueh, PR (2009) Invasive candidiasis: an overview from Taiwan. J Formos Med Assoc聽=聽Taiwan yi zhi 108: pp. 443-451 CrossRef
  32. Rubin-Preminger, JM, Kozlov, L, Goldberg, I (2008) Hydrogen-bonding and pi-pi stacking interactions in aquachloridobis(1,10-phenanthroline)cobalt(II) chloride dichloridobis(1,10-phenanthroline)cobalt(II) hexahydrate. Acta crystallogr C Crystal structure communications 64: pp. m83-m86 CrossRef
  33. Samaranayake, LP (2002) Fungal infections associated with HIV infection. Oral Dis 8: pp. 151-160 CrossRef
  34. Silva, S, Negri, M, Henriques, M, Oliveira, R, Williams, DW, Azeredo, J (2012) Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiol Rev 36: pp. 288-305 CrossRef
  35. Strain, J, Culotta, VC (1996) Copper ions and the regulation of Saccharomyces cerevisiae metallothionein genes under aerobic and anaerobic conditions. Molec Gen Genet 251: pp. 139-145
  36. Rijt, SH, Sadler, PJ (2009) Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discov Today 14: pp. 1089-1097 CrossRef
  37. Weissman, Z, Berdicevsky, I, Cavari, BZ, Kornitzer, D (2000) The high copper tolerance of Candida albicans is mediated by a P-type ATPase. Proc Natl Acad Sci USA 97: pp. 3520-3525 CrossRef
  38. Wisplinghoff, H, Bischoff, T, Tallent, SM, Seifert, H, Wenzel, RP, Edmond, MB (2004) Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39: pp. 309-317 CrossRef
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Physical Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1572-8773

文摘

The minimal inhibitory concentrations (MICs) of copper and cobalt based dimeric pyrophosphate complexes with capping 1,10-phenanthroline groups on clinical isolates of C. albicans (28 isolates), C. krusei (20 isolates) and C. tropicalis (20 isolates) are reported. C. albicans was inhibited by the cobalt complex better than by the copper complex, while C. krusei demonstrated the opposite results. C. tropicalis showed similar sensitivities to both metals in terms of calculated MIC50 values but was more sensitive to cobalt when MIC90 values were noted. Knockout strains of C. albicans that had the copper efflux protein P-type ATPase (CRP1), the copper binding metallothionein CUP1 or both CRP1/CUP1 removed clearly demonstrate that the origins of copper resistant in C. albicans lies primarily in the P-type ATPase, with the MT playing an important secondary role in the absence of the efflux protein. This study suggests that certain strains of Candida have evolved to protect against particular metal ions and that in the case of C. albicans, a primary invasive fungal species, cobalt may be a good starting-point for new therapeutic development.