Mass Spectrometry in Clinical Microbiology and Infectious Diseases

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• 作者：Frank Fleurbaaij (1)
  Hans C. van Leeuwen (1)
  Oleg I. Klychnikov (2)
  Ed J. Kuijper (1)
  Paul J. Hensbergen (2)
  
  1. Section Experimental Microbiology ; Department of Medical Microbiology ; Leiden University Medical Center ; PO Box 9600 ; 2300 RC ; Leiden ; The Netherlands
  2. Center for Proteomics and Metabolomics ; Leiden University Medical Center ; PO Box 9600 ; 2300 RC ; Leiden ; The Netherlands
  
• 关键词：Microbiology ; Mass spectrometry ; PCR ; MALDI ; ToF MS ; Proteomics ; Metabolomics ; Clinical
• 刊名：Chromatographia
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：78
• 期：5-6
• 页码：379-389
• 全文大小：488 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Organic Chemistry
  Pharmacy
  Biochemistry
  Plant Sciences
  Measurement Science and Instrumentation
  
• 出版者：Vieweg Verlag
• ISSN：1612-1112

文摘

Mass spectrometry (MS) has a long history in which it has undergone a transformation from an instrument used in elemental analysis to a flexible tool for bio-analysis. Recent years have seen the adoption of the mass spectrometer in the (clinical) microbiology laboratory, as a tool for both research and diagnostic purposes. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF MS) has been the frontrunner in routine identification, enabling pathogen identification through whole cell extract profiling. However, many more MS-based applications related to clinical microbiology and the study of infectious diseases exist. This review provides an overview of recently published studies using MS for, i.e., pathogen identification, exploration of potential diagnostic makers and dosage studies, exemplifying the versatility of the technique and its potential applications in the study of microbes.