Elasto-inertial microfluidics for bacteria separation from whole blood for sepsis diagnostics
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- 作者：Muhammad Asim Faridi ; Harisha Ramachandraiah…
- 关键词：Micro particle separation ; Elasto ; inertial microfluidics ; Sepsis ; Sample preparation
- 刊名：Journal of Nanobiotechnology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：15
- 期：1
- 全文大小：2774KB
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Biotechnology; Nanotechnology; Molecular Medicine;
- 出版者：BioMed Central
- ISSN：1477-3155
- 卷排序：15
文摘
BackgroundBloodstream infections (BSI) remain a major challenge with high mortality rate, with an incidence that is increasing worldwide. Early treatment with appropriate therapy can reduce BSI-related morbidity and mortality. However, despite recent progress in molecular based assays, complex sample preparation steps have become critical roadblock for a greater expansion of molecular assays. Here, we report a size based, label-free, bacteria separation from whole blood using elasto-inertial microfluidics.