Inkjet printing of insulin microneedles for transdermal delivery

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• 作者：Steven Ross ; Nicolaos Scoutaris…
• 关键词：Inkjet printing ; Microneedles ; Insulin ; Transdermal delivery
• 刊名：Drug Delivery and Translational Research
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：5
• 期：4
• 页码：451-461
• 全文大小：2,168 KB
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  24.Schmidt S, Uhlig K, Du
• 作者单位：Steven Ross (1) (2)
  Nicolaos Scoutaris (1)
  Dimitrios Lamprou (2)
  David Mallinson (2)
  Dennis Douroumis (1)
  
  1. Faculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent, ME4 4TB, UK
  2. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, Glasgow, G40NR, Scotland, UK
  
• 刊物主题：Pharmaceutical Sciences/Technology;
• 出版者：Springer US
• ISSN：2190-3948

文摘

Inkjet printing technology was used to apply insulin polymeric layers on metal microneedles for transdermal delivery. A range of various polymers such as gelatin (GLN), polyvinyl caprolactame-polyvinyl acetate-polyethylene glycol (SOL), poly(2-ethyl-2-oxazoline) (POX) and trehalose (THL) were assessed for their capacity to form thin uniform and homogeneous layers that preserve insulin intact. Atomic force microscopy (AFM) showed homogeneous insulin–polymer layers without any phase separation while SOL demonstrated the best performance. Circular discroism (CD) analysis of rehydrated films showed that insulin’s alpha helices and β–sheet were well preserved for THL and SOL. In contrast, GLN and POX insulin layers revealed small band shifts indicating possible conformational changes. Insulin release in Franz diffusion cells from MNs inserted into porcine skin showed rapid release rates for POX and GLN within the first 20?min. Inkjet printing was proved an effective approach for transdermal delivery of insulin in solid state.