This paper reports a study of overall migration of polethylene terephthalate (PET) components into Algerian mineral water aiming to elaborate a mathematical methodology that predicts the overall migration value. Several experiments were carried out on PET samples of 1.5 L and 33 cL bottles respecting the European Regulation (EU) No 10-2011. The obtained results allowed to establish a polynomial model based on the kinetic of the effects of temperature and PET thickness on the overall migration value. This model was developed through a set of 22 factorial plans, coupled to a fundamental model of kinetic migration. This innovative approach leads to a time-dependent equation that offers a better handling of the relatively complex phenomenon of container–content interactions.