A glimpse of the ERM proteins
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- 作者：Godwin A. Ponuwei
- 关键词：Ezrin ; Radixin ; Moesin ; Plasma membrane ; Phospholipids ; Cancer
- 刊名：Journal of Biomedical Science
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：23
- 期：1
- 全文大小：658 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Biomedicine - 出版者：Springer Netherlands
- ISSN：1423-0127
文摘
In all eukaryotes, the plasma membrane is critically important as it maintains the architectural integrity of the cell. Proper anchorage and interaction between the plasma membrane and the cytoskeleton is critical for normal cellular processes. The ERM (ezrin-radixin-moesin) proteins are a class of highly homologous proteins involved in linking the plasma membrane to the cortical actin cytoskeleton. This review takes a succinct look at the biology of the ERM proteins including their structure and function. Current reports on their regulation that leads to activation and deactivation was examined before taking a look at the different interacting partners. Finally, emerging roles of each of the ERM family members in cancer was highlighted.