Anaemia correction in predialysis elderly patients: influence of the antihypertensive therapy on darbepoietin dose
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- 作者：Pedro Le?o Neves ; Alexandre Baptista ; Elsa Morgado ; Alfonso Iglesias ; Hermínio Carrasqueira ; Marília Faísca ; Carla Soares and Ana P. Silva
- 关键词：Antihypertensive drugs ; Darbepoietin ; Predialysis
- 刊名：International Urology and Nephrology
- 出版年：2007
- 出版时间：June, 2007
- 年：2007
- 卷：39
- 期：2
- 页码：685-689
- 全文大小：130 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Nephrology
Urology and Andrology - 出版者：Springer Netherlands
- ISSN：1573-2584
文摘
Anaemia and hypertension are common in patients with chronic renal insufficiency. The correction of anaemia with erythropoiesis stimulating agents (ESA) can improve survival and decrease the decline of renal function. Angiotensin converting-enzyme inhibitors (ACEI) and angiotensin II receptor blockers (AIIRA) can also slow the progression of renal failure, but the blockade of the renin-angiotensin system can worsen anaemia. The aim of our study was to assess the impact of antihypertensive therapy (ACEI plus AIIRA) in the requirements of darbepoietin in a group of elderly predialysis patients. We included 71 patients (m = 39, f = 32), mean age of 76.3 years with a mean creatinine clearance of 17.5 ml/min. Patients were divided in two groups according to their antihypertensive therapy: G-I patients under ACEI or AIIRA therapy and G-II normotensive patients or hypertensive patients under antihypertensive drugs other than ACEI or AIIRA. The groups were compared regarding demographic, nutritional, biochemical and inflammatory parameters. We also compared the mean darbepoietin dose. In GI the mean dose of darbepoietin was higher than in GII (0.543 vs. 0.325 μg/kg/week, P = 0.032). We did not find any difference regarding other parameters analysed. We conclude that ACEI and AIIRA can increase the needs of darbepoietin in predialysis elderly patients. However, when formally indicated to treat hypertension in a specific patient, they should not be switched to another antihypertensive agent. Instead, in such cases, higher doses of ESA should be used, if necessary.