Endogene Faktoren, Gene und Hautalterung

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• 作者：E. Makrantonaki ; G. P. Pfeifer…
• 关键词：Genetik ; Mutationen ; Genexpression ; Epigenetik ; Hauthomöostase ; Genetics ; Mutations ; Gene expression ; Epigenetics ; Skin homeostasis
• 刊名：Der Hautarzt
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：67
• 期：2
• 页码：103-106
• 全文大小：315 KB
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• 作者单位：E. Makrantonaki (1) (2)
  G. P. Pfeifer (3)
  Prof. Dr. med. Prof. h.c. Dr. h.c. C. C. Zouboulis (2)
  
  1. Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Albert-Einstein Allee 23, Life Sciences Building N27, James-Franck Ring/ Meyerhofstr. 11c, 89081, Ulm, Deutschland
  2. Klinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06487, Dessau, Deutschland
  3. Center for Epigenetics, Van Andel Research Institute, 333 Bostwick Avenue NE, 49503, Grand Rapids, MI, USA
  
• 刊物主题：Dermatology; Immunology; Allergology; Proctology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1173

文摘

Skin aging is determined by a combination of endogenous and environmental influences, including epigenetic, posttranslational, microbial, and lifestyle factors. In particular genetic changes, programmed or not, play a pivotal role and understanding of these complex mechanisms may contribute to the prevention of age-related diseases and extension of healthy lifespan. In this article, new knowledge about genes and biological processes that can significantly affect skin homeostasis in old age and can lead to the typical morphological and physiological characteristics of aging skin are summarized. Keywords Genetics Mutations Gene expression Epigenetics Skin homeostasis