Fetale DNA-Analyse aus mütterlichem Blut

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• 作者：PD Dr. U. Friebe-Hoffmann ; Dr. K. Lato
• 关键词：SchlüsselwörterPränatale Diagnostik ; Medizinethik ; Mutationen ; DNA ; Sequenzierung ; Fetale Aneuploidie
• 刊名：Der Gyn?kologe
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：49
• 期：11
• 页码：879-883
• 全文大小：402 KB
• 刊物主题：Gynecology; Obstetrics/Perinatology; Endocrinology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1433-0393
• 卷排序：49

文摘

With the introduction of non-invasive prenatal tests (NIPT) in Germany in 2012 a new era in prenatal diagnostics was launched. With these methods chromosomal aberrations in the fetal genome can be identified with up to 99 % certainty. This offers pregnant women a low-risk early, fast and safe alternative to conventional invasive diagnostics; however, apart from all the enthusiasm with medical progress, the general availability of prenatal tests raises concerns and questions, which necessitate an ethical discussion as well as a professional debate about the implementation.