Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke

详细信息    查看全文

• 作者：Rika Sakuma ; Maiko Kawahara ; Akiko Nakano-Doi ; Ai Takahashi…
• 关键词：Ischemia ; Stroke ; Vascular stem cells ; Microglia ; Pericytes
• 刊名：Journal of Neuroinflammation
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：13
• 期：1
• 全文大小：3,471 KB
• 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
• 出版者：BioMed Central
• ISSN：1742-2094

文摘

Background Microglia are the resident macrophage population of the central nervous system (CNS) and play essential roles, particularly in inflammation-mediated pathological conditions such as ischemic stroke. Increasing evidence shows that the population of vascular cells located around the blood vessels, rather than circulating cells, harbor stem cells and that these resident vascular stem cells (VSCs) are the likely source of some microglia. However, the precise traits and origins of these cells under pathological CNS conditions remain unclear.