The incidence of monozygotic twinning in assisted reproductive technology: Analysis based on results from the 2010 Japanese ART national registry

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• 作者：Takashi Nakasuji (1) (6)
  Hidekazu Saito (1)
  Ryuichiro Araki (2)
  Aritoshi Nakaza (3)
  Akira Nakashima (3)
  Akira Kuwahara (4)
  Osamu Ishihara (5)
  Minoru Irahara (4)
  Toshiro Kubota (6)
  Yasunori Yoshimura (7)
  Tetsuro Sakumoto (3)
  
• 关键词：Monozygotic twinning ; Assisted hatching ; Blastocyst transfer ; Frozen ; thawed embryo transfer ; National ART registry system
• 刊名：Journal of Assisted Reproduction and Genetics
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：31
• 期：7
• 页码：803-807
• 全文大小：137 KB
• 参考文献：1. Ministry of Health, Labour and Welfare. Statistics information-white book. http://www.mhlw.go.jp/ Accessed 20 December 2013.
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• 作者单位：Takashi Nakasuji (1) (6)
  Hidekazu Saito (1)
  Ryuichiro Araki (2)
  Aritoshi Nakaza (3)
  Akira Nakashima (3)
  Akira Kuwahara (4)
  Osamu Ishihara (5)
  Minoru Irahara (4)
  Toshiro Kubota (6)
  Yasunori Yoshimura (7)
  Tetsuro Sakumoto (3)
  
  1. Division of Reproductive Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, Japan
  6. Comprehensive Reproductive Medicine, Regulation of Internal Environment and Reproduction, Systemic Organ Regulation, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
  2. Community Health Science Center, Saitama Medical University, Saitama, Japan
  3. Alba Okinawa Clinic, Okinawa, Japan
  4. Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima, Tokushima, Japan
  5. Department of Obstetrics and Gynecology, Saitama Medical University, Saitama, Japan
  7. Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan
  
• ISSN：1573-7330

文摘

Purpose To assess the incidence of monozygotic twinning (MZT) among cases undergoing assisted reproductive technology (ART) treatment. Methods We performed a retrospective observational study and analyzed the data of patients who were registered in the national ART registry system of Japan from January to December 2010; only the data of patients with single embryo transfer (ET) were included. Results Of 30,405 pregnancies, 425 resulted in MZT following fresh and frozenthawed ET. The MZT incidence among women undergoing ART was 1.4?%. Multiple logistic regression analysis indicated that cases undergoing fresh and frozen-thawed ET, blastocyst transfer had a significantly increased MZT rate (P--.01). Assisted hatching (AH) and frozen-thawed ET and maternal age did not significantly affect the MZT incidence. Of 8510 fresh ET pregnancies, 104 resulted in MZT. Multiple logistic regression analysis indicated that blastocyst transfer significantly increased the MZT rate in cases undergoing fresh ET. Ovarian stimulation, intracytoplasmic sperm injection, AH, and maternal age did not significantly affect the MZT incidence. Conclusions Blastocyst transfer was associated with an increased MZT incidence. We have to be aware of the potential risk of MZT caused by blastocyst transfer. However, further studies are required to assess the correlation among specific AH types, embryo culture conditions, and MZT incidence.