Cyclosporine A induced histological changes of Cathepsin L and CD2AP expression in renal glomeruli and tubules

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• 作者：Keisuke Sugimoto ; Tomoki Miyazawa ; Takuji Enya…
• 关键词：Cathepsin L ; CD2AP ; Childhood ; Cyclosporine A ; Cyclosporine nephrotoxicity ; Nephrotic syndrome
• 刊名：Clinical and Experimental Nephrology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：21
• 期：1
• 页码：83-91
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Nephrology; Urology;
• 出版者：Springer Japan
• ISSN：1437-7799
• 卷排序：21

文摘

BackgroundCyclosporine A (CsA) is used globally as an immunosuppressant for the treatment of immune-mediated nephrotic syndrome (NS). However, its long-term use causes nephrotoxicity characterized by tubulointerstitial injury and glomerulosclerosis. The present study aimed to investigate the associations between histomorphological findings and immunohistological expression of Cathepsin L (CatL) and CD2-associated protein (CD2AP) in patients with NS mediated with CsA.