Isoflurane decreases proliferation and differentiation, but none of the effects persist in human embryonic stem cell-derived neural progenitor cells

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• 作者：Hye-Min Sohn ; Hye Young Kim ; Seongjoo Park ; Sung-Hee Han…
• 关键词：Neurotoxicity ; Isoflurane ; Embryonic stem cells ; Neurodevelopment
• 刊名：Journal of Anesthesia
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：1
• 页码：36-43
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Anesthesiology; Pain Medicine; Intensive / Critical Care Medicine; Emergency Medicine;
• 出版者：Springer Japan
• ISSN：1438-8359
• 卷排序：31

文摘

PurposeVolatile anesthetics are a potential risk for cognitive impairment in the developing brain. Isoflurane causes cell death, reduces neurogenesis, and changes neuronal differentiation. In this study, the effects of a single isoflurane exposure on the developing human brain were evaluated using human embryonic stem cell (hESC)-derived neural progenitor cells (NPCs).