A novel porphyrin–polypyridyl ruthenium(II) hybrid. Synthesis, characterization and photoinduced DNA cleavage activity

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• 作者：Jie Liu ; Jin-Wang Huang ; Ping Zhao ; Bo Fu ; Han-Cheng Yu ; Liang-Nian Ji and Hong Li
• 刊名：Transition Metal Chemistry
• 出版年：2006
• 出版时间：November, 2006
• 年：2006
• 卷：31
• 期：8
• 页码：1040-1044
• 全文大小：255 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1572-901X

文摘

A novel porphyrin–polypyridyl ruthenium(II) hybrid compound, [C₄-TPP-(ip)Ru(phen)₂](ClO₄)₂ (TPP = 5,10, 15,20-tetraphenylporphyrin, ip = imidazo[4,5-f][1,10]phenanthroline and phen = 1,10-Phenanthroline), in which a polypyridyl ruthenium(II) moiety is linked to a porphyrin moiety by a butyl chain, has been synthesized by the reaction of (C₄ip)TPP with cis-Ru(phen)₂Cl₂ in glacial acetic acid under an Ar atmosphere and characterized by elemental analysis, i.r., 1H-n.m.r., u.v.–vis., ESI-MS and electrochemistry. Its photoinduced DNA cleavage activity was investigated preliminarily. It has been found that the hybrid compound promoted photocleavage of plasmid pBR 322 DNA upon irradiation. Singlet oxygen (1O₂) is suggested to be the reactive species responsible for the cleavage.