A Computational Approach for Designing a Universal Epitope-Based Peptide Vaccine Against Nipah Virus

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• 作者：Mohammad Tuhin Ali ; Mohammed Monzur Morshed…
• 关键词：Epitope ; based vaccine ; HLA ligand ; Population coverage ; Zoonotic virus
• 刊名：Interdisciplinary Sciences: Computational Life Sciences
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：7
• 期：2
• 页码：177-185
• 全文大小：1,693 KB
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• 作者单位：Mohammad Tuhin Ali (1)
  Mohammed Monzur Morshed (1)
  Faizule Hassan (2)
  
  1. Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 1000, Bangladesh
  2. Department of Chemistry and Biochemistry, Miami University, 107 Hughes Laboratory, Oxford, OH, 45056, USA
  
• 刊物主题：Computer Appl. in Life Sciences; Computational Biology/Bioinformatics; Statistics for Life Sciences, Medicine, Health Sciences; Theoretical and Computational Chemistry; Theoretical, Mathematical and Computational Physics; Computational Science and Engineering;
• 出版者：International Association of Scientists in the Interdisciplinary Areas
• ISSN：1867-1462

文摘

Nipah virus (NiV) is highly pathogenic single-stranded negative sense RNA virus. It can cause severe encephalitis and respiratory disease in humans. In addition, NiV infects a large range of host including mammals. As a result of its higher zoonotic potential and pathogenicity for human, it has been rated as an alert in recent days. A therapeutic treatment or vaccines has become elusive to fight against this virus. In this study, the attachment (G) and fusion (F) glycoproteins of NiV, responsible for the viral attachment and entry to the host cell, were selected to develop epitope-based vaccine against Nipah virus. Epitopes were identified from the conserved region of G and F protein of NiV. Both B-cell and T-cell immunity were checked to affirm it that these epitopes will be able to induce humoral and cellular immunity. A total of 6 T-cell epitopes and 19 significant HLA–epitope interactions were identified. Eventually it has shown an acceptable percentage in population coverage (46.45 %) and efficient binding with HLA molecule by molecular docking study. Keywords Epitope-based vaccine HLA ligand Population coverage Zoonotic virus