The physiological effects of hypobaric hypoxia versus normobaric hypoxia: a systematic review of crossover trials

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• 作者：Jonny Coppel (1)
  Philip Hennis (1)
  Edward Gilbert-Kawai (1)
  Michael PW Grocott (1) (2) (3) (4)
  
  1. University College London Centre for Altitude Space and Extreme Environment Medicine ; UCLH NIHR Biomedical Research Centre ; Institute of Sport and Exercise Health ; 170 Tottenham Court Road ; London ; W1T 7HA ; UK
  2. Integrative Physiology and Critical Illness Group ; Clinical and Experimental Sciences ; Mailpoint 810 ; Sir Henry Wellcome Laboratories ; Faculty of Medicine ; University of Southampton ; University Hospital Southampton NHS Foundation Trust ; Tremona Road ; Southampton ; SO16 6YD ; UK
  3. Anaesthesia and Critical Care Research Unit ; University Hospital Southampton NHS Foundation Trust ; Mailpoint 27 ; D Level ; Centre Block ; Tremona Road ; Southampton ; SO16 6YD ; UK
  4. NIHR Southampton Respiratory Biomedical Research Unit ; Southampton ; SO16 5ST ; UK
  
• 关键词：Normobaric hypoxia ; Hypobaric hypoxia ; Altitude
• 刊名：Extreme Physiology & Medicine
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：4
• 期：1
• 全文大小：1,397 KB
• 参考文献：1. Grocott, M, Montgomery, H, Vercueil, A (2007) High-altitude physiology and pathophysiology: implications and relevance for intensive care medicine. Crit Care 11: pp. 203 CrossRef
  2. Grant, S, MacLeod, N, Kay, JW, Watt, M, Patel, S, Paterson, A (2002) Sea level and acute responses to hypoxia: do they predict physiological responses and acute mountain sickness at altitude?. Brit J Sport Med 36: pp. 141-146 CrossRef
  3. Millet, GP, Faiss, R, Brocherie, F, Girard, O (2013) Hypoxic training and team sports: a challenge to traditional methods?. Brit J Sport Med 47: pp. 6-7 CrossRef
  4. DeHart, RLE (1996) Fundamentals of aerospace medicine. Williams and Wilkins, Baltimore
  5. Conkin, J, Wessel, JH (2008) Critique of the equivalent air altitude model. Aviat Space Envir Md 79: pp. 975-982 CrossRef
  6. Self, DA, Mandella, JG, Prinzo, OV, Forster, EM, Shaffstall, RM (2011) Physiological equivalence of normobaric and hypobaric exposures of humans to 25,000 feet (7620聽m). Aviat Space Envir Md 82: pp. 97-103 CrossRef
  7. Debevec, T, Millet, GP (2014) Discerning normobaric and hypobaric hypoxia: significance of exposure duration. J Appl Physiol 116: pp. 1255-5 CrossRef
  8. Olivier, G, Koehle, MS, Guenette, JA, Verges, S, Chapman, RF, Conkin, J (2012) Comments on point: counterpoint: hypobaric hypoxia induces/does not induce different responses from normobaric hypoxia. J Appl Physiol 112: pp. 1788-1794 CrossRef
  9. Muza, SR (2007) Military applications of hypoxic training for high-altitude operations. Med Sci Sports Exerc 39: pp. 1625-1631 CrossRef
  10. Millet, GP, Faiss, R, Pialoux, V (2013) Evidence for differences between hypobaric and normobaric hypoxia is conclusive. Exerc Sport Sci Rev 41: pp. 133 CrossRef
  11. Conkin, J (2011) PH2O and simulated hypobaric hypoxia. Aviat Space Envir Md 82: pp. 1157-1158 CrossRef
  12. Faiss, R, Pialoux, V, Sartori, C, Faes, C, Deriaz, O, Millet, GP (2013) Ventilation, oxidative stress, and nitric oxide in hypobaric versus normobaric hypoxia. Med Sci Sports Exerc 45: pp. 253-260 CrossRef
  13. Loeppky, JA, Icenogle, M, Scotto, P, Robergs, R, HinghoferSzalkay, H, Roach, RC (1997) Ventilation during simulated altitude, normobaric hypoxia and normoxic hypobaria. Resp Physiol 107: pp. 231-239 CrossRef
  14. Loeppky, JA, Roach, RC, Maes, D, Hinghofer-Szalkay, H, Roessler, A, Gates, L (2005) Role of hypobaria in fluid balance response to hypoxia. High Alt Med Biol 6: pp. 60-71 CrossRef
  15. Miyagawa, K, Kamijo, Y, Ikegawa, S, Goto, M, Nose, H (2011) Reduced hyperthermia-induced cutaneous vasodilation and enhanced exercise-induced plasma water loss at simulated high altitude (3,200 m) in humans. J Appl Physiol 110: pp. 157-165 CrossRef
  16. Roach, RC, Loeppky, JA, Icenogle, MV (1996) Acute mountain sickness: increased severity during simulated altitude compared with normobaric hypoxia. J Appl Physiol 81: pp. 1908-1910
  17. Savourey, G, Launay, JC, Besnard, Y, Guinet, A, Travers, S (2003) Normo- and hypobaric hypoxia: are there any physiological differences?. Eur J Appl Physiol 89: pp. 122-126 CrossRef
  18. Savourey, G, Launay, JC, Besnard, Y, Guinet-Lebreton, A, Alonso, A, Sauvet, F (2007) Normo or hypobaric hypoxic tests: propositions for the determination of the individual susceptibility to altitude illnesses. Eur J Appl Physiol 100: pp. 193-205 CrossRef
  19. Hemmingsson, T, Linnarsson, D (2009) Lower exhaled nitric oxide in hypobaric than in normobaric acute hypoxia. Resp Physiol Neurobi 169: pp. 74-77 CrossRef
  20. Naughton, MT, Rochford, PD, Pretto, JJ, Pierce, RJ, Cain, NF, Irving, LB (1995) Is normobaric simulation of hypobaric hypoxia accurate in chronic air-flow limitation. Am J Resp Crit Care 152: pp. 1956-1960 CrossRef
  21. Basualto-Alarcon, C, Rodas, G (2012) Cardiorespiratory parameters during submaximal exercise under acute exposure to normobaric and hypobaric hypoxia. Apunts Med Esport 47: pp. 65-72 CrossRef
  22. Tucker, A, Reeves, JT, Robertshaw, D, Grover, RF (1983) Cardiopulmonary response to acute altitude exposure鈥攚ater loading and denitrogenation. Resp Physiol 54: pp. 363-380 CrossRef
  23. Degache, F, Larghi, G, Faiss, R, Deriaz, O, Millet, G (2012) Hypobaric versus normobaric hypoxia: same effects on postural stability?. High Alt Med Biol 13: pp. 40-45 CrossRef
  24. Isa, KBM, Kawasaki, N, Ueyama, K, Sumii, T, Kudo, S (2011) Effect of cold exposure and shear stree on endothelial nitric oxide synthase activation. Biochem Biophys Res Commun 412: pp. 318-322 CrossRef
  25. West, JB, Milledge, JS, Schoene, RB, Luks, A (2013) High altitude medicine and physiology. CRC Press/Taylor & Francis Group, Boca Raton
  26. Fulco, CS, Beidleman, BA, Muza, SR (2013) Effectiveness of preacclimatization strategies for high-altitude exposure. Exerc Sport Sci Rev 41: pp. 55-63 CrossRef
  
• 刊物主题：Human Physiology; Emergency Medicine; Intensive / Critical Care Medicine; Cardiology; Pneumology/Respiratory System; Sports Medicine;
• 出版者：BioMed Central
• ISSN：2046-7648

文摘

Much hypoxia research has been carried out at high altitude in a hypobaric hypoxia (HH) environment. Many research teams seek to replicate high-altitude conditions at lower altitudes in either hypobaric hypoxic conditions or normobaric hypoxic (NH) laboratories. Implicit in this approach is the assumption that the only relevant condition that differs between these settings is the partial pressure of oxygen (PO2), which is commonly presumed to be the principal physiological stimulus to adaptation at high altitude. This systematic review is the first to present an overview of the current available literature regarding crossover studies relating to the different effects of HH and NH on human physiology. After applying our inclusion and exclusion criteria, 13 studies were deemed eligible for inclusion. Several studies reported a number of variables (e.g. minute ventilation and NO levels) that were different between the two conditions, lending support to the notion that true physiological difference is indeed present. However, the presence of confounding factors such as time spent in hypoxia, temperature, and humidity, and the limited statistical power due to small sample sizes, limit the conclusions that can be drawn from these findings. Standardisation of the study methods and reporting may aid interpretation of future studies and thereby improve the quality of data in this area. This is important to improve the quality of data that is used for improving the understanding of hypoxia tolerance, both at altitude and in the clinical setting.