Clustering reveals limits of parameter identifiability in multi-parameter models of biochemical dynamics
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  • 作者:Karol Nienałtowski ; Michał Włodarczyk ; Tomasz Lipniacki…
  • 刊名:BMC Systems Biology
  • 出版年:2015
  • 出版时间:December 2015
  • 年:2015
  • 卷:9
  • 期:1
  • 全文大小:678 KB
  • 刊物主题:Bioinformatics; Systems Biology; Simulation and Modeling; Computational Biology/Bioinformatics; Physiological, Cellular and Medical Topics; Algorithms;
  • 出版者:BioMed Central
  • ISSN:1752-0509
文摘
Background Compared to engineering or physics problems, dynamical models in quantitative biology typically depend on a relatively large number of parameters. Progress in developing mathematics to manipulate such multi-parameter models and so enable their efficient interplay with experiments has been slow. Existing solutions are significantly limited by model size.

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