Increased Act1/IL-17R expression in Hirschsprung’s disease

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• 作者：Christian Tomuschat ; Anne Marie O’Donnell ; David Coyle…
• 关键词：Hirschsprung’s disease ; Act1 ; IL17R ; Hirschsprung’s ; associated enterocolitis (HAEC) ; Inflammatory bowel disease
• 刊名：Pediatric Surgery International
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：32
• 期：12
• 页码：1201-1207
• 全文大小：860 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pediatrics
  Surgery
  Pediatric Surgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1437-9813
• 卷排序：32

文摘

PurposeHirschsprung’s disease-associated enterocolitis (HAEC) is the most common cause of morbidity and mortality in Hirschsprung’s disease (HSCR). Altered intestinal epithelial barrier function is implicated in the pathogenesis of HAEC. IL-17 is a proinflammatory cytokine that plays a crucial role in host defense against microbial organisms in the development of inflammatory diseases. Act1 is an essential adaptor molecule required for the IL-17-mediated inflammatory responses via interaction with IL-17 receptor (IL-17R). We designed this study to investigate the hypothesis that Act1/Il-17R expression is upregulated in HSCR.