Differential timing of neurogenesis underlies dorsal-ventral topographic projection of olfactory sensory neurons

详细信息    查看全文

• 作者：Eerdunfu ; Naoki Ihara ; Bao Ligao ; Yuji Ikegaya ; Haruki Takeuchi
• 关键词：Olfactory receptor ; Olfactory sensory neuron ; Neural circuit formation ; Topographic map ; Zonal organization ; Neurogenesis
• 刊名：Neural Development
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：1581KB
• 刊物主题：Neurosciences; Developmental Biology; Neurobiology;
• 出版者：BioMed Central
• ISSN：1749-8104
• 卷排序：12

文摘

BackgroundThe mammalian primary olfactory system has a spatially-ordered projection in which olfactory sensory neurons (OSNs) located in the dorsomedial (DM) and ventrolateral (VL) region of the olfactory epithelium (OE) send their axons to the dorsal and ventral region of the olfactory bulb (OB), respectively. We previously found that OSN axonal projections occur sequentially, from the DM to the VL region of the OE. The differential timing of axonal projections is important for olfactory map formation because early-arriving OSN axons secrete guidance cues at the OB to help navigate late-arriving OSN axons. We hypothesized that the differential timing of axonal projections is regulated by the timing of OSN neurogenesis. To test this idea, we investigated spatiotemporal patterns of OSN neurogenesis during olfactory development.