The crosstalk between long non-coding RNAs and PI3K in cancer

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• 作者：Leonidas Benetatos ; Evangelos Voulgaris ; Georgios Vartholomatos
• 关键词：Long non ; coding RNAs ; PI3K ; Cancer ; Differentiation ; Metastasis
• 刊名：Medical Oncology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：34
• 期：3
• 全文大小：
• 刊物主题：Oncology; Hematology; Pathology; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-131X
• 卷排序：34

文摘

Long non-coding RNAs (lncRNAs) are able to positively or negatively regulate other genes expression in cis or in trans. Their effect can be achieved through RNA–protein, RNA–DNA, or RNA–RNA interactions. They can recruit transcription factors and act as scaffolds or guides for chromatin-modifying enzymes. PI3K kinases transform external stimuli to intracellular signals regulating cell growth, differentiation, proliferation, survival, intracellular trafficking, cytoskeletal changes, cell migration and motility, and metabolism. PI3K is activated in cancer and affects several aspects of oncogenesis. LncRNAs and PI3K have been shown to be interconnected in several different cancer subtypes enhancing aberrant cell proliferation, epithelial-to-mesenchymal transition, migration and invasion, and also cancer cell metabolism. In this review, we have assembled recent data describing the interaction between lncRNAs and PI3K and the results of such interaction.