The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures

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• 作者：Catherine O’Sullivan ; Anna Schubart ; Anis K. Mir…
• 关键词：Sphingosine ; 1 phosphate receptors (S1PRs) ; Siponimod (BAF312) ; Aastrocytes ; Demyelination ; Krabbe disease
• 刊名：Journal of Neuroinflammation
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：13
• 期：1
• 全文大小：1,913 KB
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• 作者单位：Catherine O’Sullivan (1)
  Anna Schubart (2)
  Anis K. Mir (2)
  Kumlesh K. Dev (1)
  
  1. Drug Development, School of Medicine, Trinity College, Dublin, Ireland
  2. Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
  
• 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
• 出版者：BioMed Central
• ISSN：1742-2094

文摘

Background BAF312 (Siponimod) is a dual agonist at the sphingosine-1 phosphate receptors, S1PR1 and S1PR5. This drug is currently undergoing clinical trials for the treatment of secondary progressive multiple sclerosis (MS). Here, we investigated the effects of BAF312 on isolated astrocyte and microglia cultures as well as in slice culture models of demyelination.