Oxygen ultra-fine bubbles water administration prevents bone loss of glucocorticoid-induced osteoporosis in mice by suppressing osteoclast differentiation

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• 作者：T. Noguchi ; K. Ebina ; M. Hirao ; T. Morimoto ; K. Koizumi…
• 关键词：c ; Fos ; Glucocorticoid ; induced osteoporosis (GIO) ; Nuclear factor of activated T ; cells 1 (NFATc1) ; Osteoblasts ; Osteoclasts ; Oxygen ultra ; fine bubbles (OUB)
• 刊名：Osteoporosis International
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：28
• 期：3
• 页码：1063-1075
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Orthopedics; Endocrinology; Rheumatology;
• 出版者：Springer London
• ISSN：1433-2965
• 卷排序：28

文摘

SummaryOxygen ultra-fine bubbles (OUB) saline injection prevents bone loss of glucocorti\coid-induced osteoporosis in mice, and OUB inhibit osteoclastogenesis via RANK-TRAF6-c-Fos-NFATc1 signaling and RANK-p38 MAPK signaling in vitro.