RFLP). Results No statistical difference was observed in allele distributions and frequencies of the two SNPs between control and CI groups. However, the percentage of atherosclerosis in CI group was significantly higher than that in the control group (p?p?p?=?0.002). Logistic association analysis showed no correlations between cerebral infarction and different alleles (p?>?0.05). Conclusion T allele of rs768529 may be a risk factor for the formation of the carotid vulnerable plaque in Chinese Hunan Han population." />
Association of oxysterol binding protein-related protein 9 polymorphism with cerebral infarction in Hunan Han population
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  • 作者：Lingjuan Li (1)
    Geyue Qu (1)
    Mingyue Wang (2)
    Qing Huang (1)
    Yunhai Liu (1)
  • 关键词：Oxysterol binding protein ; related protein 9 ; Clinical phenotypes ; Polymorphism ; Cerebral infarction
  • 刊名：Irish Journal of Medical Science
  • 出版年：2014
  • 出版时间：September 2014
  • 年：2014
  • 卷：183
  • 期：3
  • 页码：439-448
  • 全文大小：223 KB
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  • 作者单位：Lingjuan Li (1)
    Geyue Qu (1)
    Mingyue Wang (2)
    Qing Huang (1)
    Yunhai Liu (1)

    1. Department of Neurology, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, Hunan, China
    2. Department of Neurology, Hunan Aerospace Hospital, Changsha, Hunan, China
  • ISSN：1863-4362
文摘
Background Oxysterol binding protein-related protein 9 (ORP9) may be related to the pathogenesis of cerebral infarction since it is closely related with glucose and lipid metabolism. The present study was designed to investigate the genetic relationship between ORP9 gene polymorphisms and cerebral infarction (CI) in Hunan Han population. Methods Total 544 cerebral infarction patients (60.0?±?10.3?years) and 284 healthy controls (59.0?±?9.5?years) were enrolled. Sociodemographic and clinical data of the subjects, such as age, gender, body mass index, smoking, drinking, diabetes mellitus, hypertension, systolic and diastolic blood pressures, fasting blood glucose, triglycerides, total cholesterol, low-density and high-density lipoprotein were recorded, and two single-nucleotide polymorphisms (SNPs) of ORP9 gene including rs856600 and rs768529 with high mutation annotation format (MAF) values of 0.103 and 0.485 were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-a href='/search?dc.title=RFLP&facet-content-type=ReferenceWorkEntry&sortOrder=relevance' class='reference-link webtrekk-track' gaCategory="internal-link" gaLabel="RFLP" gaAction="reference-keyword">RFLP). Results No statistical difference was observed in allele distributions and frequencies of the two SNPs between control and CI groups. However, the percentage of atherosclerosis in CI group was significantly higher than that in the control group (p?p?p?=?0.002). Logistic association analysis showed no correlations between cerebral infarction and different alleles (p?>?0.05). Conclusion T allele of rs768529 may be a risk factor for the formation of the carotid vulnerable plaque in Chinese Hunan Han population.

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