7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils

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• 作者：Gonzalo Alba ; María Edith Reyes-Quiróz ; Javier Sáenz…
• 关键词：Oxysterols ; Neutrophils ; Radical oxygen species ; Lipid metabolism ; Hemoxygenase ; 1
• 刊名：European Journal of Nutrition
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：55
• 期：8
• 页码：2485-2492
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Nutrition;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-1293
• 卷排序：55

文摘

PurposeOxysterols are cholesterol-oxygenated derivatives generated in the organism and also present in foods because of cholesterol oxidation during processing and storage. They are the natural ligands of liver X receptors (LXRs) and are generally recognized as hypocholesterolemic and anti-inflammatory molecules although this latter property is still controversial. Most oxysterol studies have been performed in macrophages, whereas the effects of oxysterols in neutrophils are poorly known. In this study, human neutrophils were exposed to two different oxysterols, 7-keto-cholesterol (7-k-chol) and 25-hydroxy-cholesterol (25-OH-chol), and their possible participation in inflammatory process was evaluated.