TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer

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• 作者：Meiying Zhang ; Guanglei Zhuang ; Xiangjun Sun ; Yanying Shen…
• 关键词：Epithelial ovarian cancer ; TP53 mutation ; Genomic instability ; MDR1 copy number ; Recurrence
• 刊名：Diagnostic Pathology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：1939KB
• 刊物主题：Pathology;
• 出版者：BioMed Central
• ISSN：1746-1596
• 卷排序：12

文摘

BackgroundGenomic instability caused by mutation of the checkpoint molecule TP53 may endow cancer cells with the ability to undergo genomic evolution to survive stress and treatment. We attempted to gain insight into the potential contribution of ovarian cancer genomic instability resulted from TP53 mutation to the aberrant expression of multidrug resistance gene MDR1.